PBRM1
Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene.[5][6][7]
Structure and function
Human PBRM1 is one of three unique components of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, and actin.[8][9]
Chicken PB1 possesses 5 bromodomains, 2 bromo-adjacent homology (BAH) domains, and 1 truncated high-mobility group (HMG) motif. cPB1 is also homologous to yeast Rsc1, Rsc2, and Rsc4, essential proteins that are required for cell cycle progression through mitosis.[5]
Clinical significance
PBRM1 is thought to be a
Role renal carcinoma
Loss of function mutations in PBRM1 often co-occur with loss of function mutations in the
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163939 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042323 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 11078522.
- PMID 11483580.
- ^ "Entrez Gene: PB1 polybromo 1".
- PMID 30343899.
- ^ "Q86U86 : Protein polybromo-1 (Human)". Universal Protein Resource. UniProt Consortium.
- PMID 23355908.
- PMID 21248752.
- PMID 21248752.
- PMID 28082722.
- S2CID 258311941.
- PMID 28473526.
- PMID 33850862.
- PMID 31861590.
Further reading
- Martens JA, Winston F (April 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development. 13 (2): 136–142. PMID 12672490.
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–1765. PMID 11591653.
- Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription". Nature. 414 (6866): 924–928. S2CID 4391100.
- Olave I, Wang W, Xue Y, Kuo A, Crabtree GR (October 2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes & Development. 16 (19): 2509–2517. PMID 12368262.
- Horikawa I, Barrett JC (August 2002). "cDNA cloning of the human polybromo-1 gene on chromosome 3p21". DNA Sequence. 13 (4): 211–215. S2CID 23406882.
- Sekine I, Sato M, Sunaga N, Toyooka S, Peyton M, Parsons R, et al. (April 2005). "The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer". Oncogene. 24 (16): 2735–2738. S2CID 19875372.
- Yan Z, Cui K, Murray DM, Ling C, Xue Y, Gerstein A, et al. (July 2005). "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes". Genes & Development. 19 (14): 1662–1667. PMID 15985610.
- Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, et al. (August 2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods. 2 (8): 591–598. S2CID 20475874.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. S2CID 7827573.
- Chandrasekaran R, Thompson M (April 2007). "Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions". Biochemical and Biophysical Research Communications. 355 (3): 661–666. PMID 17320048.
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