PC3

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This article is about the cancer cell line PC3. For other uses, see PC3 (disambiguation).
Properties of common prostate cancer cell lines

PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing their response to chemotherapeutic agents. PC3 cells are also used to study viral infection in mammalian cells that exhibit an immune response[1]

Description

Actin (Phalloidin) and Nuclei (DAPI) staining
PC3 cell cultured in plastic plate

The PC3 cell line was established in 1979 from bone metastasis of grade IV of

xenografts in mice to investigate the tumor environment and therapeutic drug functionality.[citation needed
]

PC3 cells have high metastatic potential compared to DU145 cells, which have a moderate metastatic potential, and to LNCaP cells, which have low metastatic potential.[5] Comparisons of the protein expression of PC3, LNCaP, and other cells have shown that PC3 is characteristic of small cell neoendocrine carcinoma.[3]

PC3 cells have low

electron microscopy revealed that PC3 cells show characteristics of a poorly-differentiated adenocarcinoma. They have features common to neoplastic cells of epithelial origins, such as numerous microvilli, junctional complexes, abnormal nuclei and nucleoli, abnormal mitochondria, annulate lamellae, and lipoidal bodies.[citation needed
]

See also

References

  1. PMID 25726926
    .
  2. PMID 447482
    .
  3. ^
    PMID 21432867
    .
  4. PMID 26188761
    .
  5. PMID 16127174
    .

External links
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