PCGF1
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Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.[5][6]
PCGF1 is a component defining the non-canonical
PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression. [12][13][14]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000115289 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069678 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 8344430.
- ^ "Entrez Gene: PCGF1 polycomb group ring finger 1".
- PMID 22325352.
- PMID 27568929.
- PMID 23523425.
- PMID 23256043.
- PMID 26151332.
- PMID 31883952.
- PMID 31029541.
- PMID 24856970.
Further reading
- Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M (August 2004). "Stem cells and cancer; the polycomb connection". Cell. 118 (4): 409–18. S2CID 16542938.
- Gong Y, Yue J, Wu X, Wang X, Wen J, Lu L, et al. (2007). "NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element". Nucleic Acids Research. 34 (21): 6158–69. PMID 17088287.
- Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (September 2006). "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets". Molecular and Cellular Biology. 26 (18): 6880–9. PMID 16943429.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
- Gong Y, Wang X, Liu J, Shi L, Yin B, Peng X, et al. (January 2005). "NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183". FEBS Letters. 579 (1): 115–21. S2CID 28187618.
- Sugishita H, Kondo T, Ito S, et al. (September 2021). "Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes". Nat Commun. 12 (5341): 5341. PMID 34504070.
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