PDGFC
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| Location (UCSC) | Chr 4: 156.76 – 156.97 Mb | Chr 3: 80.94 – 81.12 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene.[5][6] Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.[7]
Function
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.[6]
PDGF-C is a key component of the
Mouse knockout studies show that PDGF-C is required for
Interactions
PDGFC has been shown to
PDGF-C is a latent growth factor with proteolytic activation, and the processing enzyme might be controlled by the other CLP-associated genes that may indirectly connect to PDGF-C signaling. Notably, a 30-cM region on human chromosome 4, where the PDGFC gene maps, shows strong linkage association with CLP26, and clinical genetic data further suggest a potential link between PDGFC gene polymorphism and cleft lip and palate.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145431 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028019 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 19634520.
- ^ a b "Entrez Gene: PDGFC platelet derived growth factor C".
- S2CID 25066476.
- ^ PMID 15361870.
- PMID 19092777.
- PMID 11297552.
Further reading
- Li X, Pontén A, Aase K, et al. (2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor". Nat. Cell Biol. 2 (5): 302–9. S2CID 25066476.
- Tsai YJ, Lee RK, Lin SP, Chen YH (2000). "Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract". Biochim. Biophys. Acta. 1492 (1): 196–202. PMID 11004490.
- Zwerner JP, May WA (2001). "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors". Oncogene. 20 (5): 626–33. PMID 11313995.
- Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes". Circulation. 103 (18): 2242–7. PMID 11342471.
- Zwerner JP, May WA (2002). "Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines". Oncogene. 21 (24): 3847–54. PMID 12032822.
- Andrae J, Molander C, Smits A, et al. (2002). "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells". Biochem. Biophys. Res. Commun. 296 (3): 604–11. PMID 12176024.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Reigstad LJ, Sande HM, Fluge Ø, et al. (2003). "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure". J. Biol. Chem. 278 (19): 17114–20. PMID 12598536.
- Eitner F, Ostendorf T, Kretzler M, et al. (2003). "PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases". J. Am. Soc. Nephrol. 14 (5): 1145–53. PMID 12707385.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Fang L, Yan Y, Komuves LG, et al. (2004). "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle". Arterioscler. Thromb. Vasc. Biol. 24 (4): 787–92. PMID 15061151.
- Jinnin M, Ihn H, Mimura Y, et al. (2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts". J. Cell. Physiol. 202 (2): 510–7. S2CID 33954371.
- Campbell JS, Hughes SD, Gilbertson DG, et al. (2005). "Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3389–94. PMID 15728360.
- Fredriksson L, Ehnman M, Fieber C, Eriksson U (2005). "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator". J. Biol. Chem. 280 (29): 26856–62. PMID 15911618.
- Reigstad LJ, Martinez A, Varhaug JE, Lillehaug JR (2006). "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines". Exp. Cell Res. 312 (6): 782–95. PMID 16443219.
External links
- PDGFC human gene location in the UCSC Genome Browser.
- PDGFC human gene details in the UCSC Genome Browser.