PREB
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 2: 27.13 – 27.13 Mb | Chr 5: 30.95 – 30.96 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene.[5][6][7]
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138073 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045302 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10194769.
- PMID 12735795.
- ^ a b "Entrez Gene: PREB prolactin regulatory element binding".
Further reading
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. S2CID 39457788.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMID 12477932.
- Taylor Clelland CL, Levy B, McKie JM, et al. (2000). "Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome". Mamm. Genome. 11 (8): 675–681. S2CID 22946856.
External links
- PREB human gene location in the UCSC Genome Browser.
- PREB human gene details in the UCSC Genome Browser.
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |