PTTG1IP
| PTTG1IP | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 21: 44.85 – 44.87 Mb | Chr 10: 77.42 – 77.43 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1), also known as PTTG1-binding factor (PBF), is a poorly characterised protein that in humans is encoded by the PTTG1IP gene[5][6][7] located within the chromosomal region 21q22.3.[8]
Structure
The encoded protein is composed of 180 amino acids and has a predicted molecular mass of 22
Function
Although PTTG1IP is ubiquitously expressed in normal human tissues, its exact function remains elusive.[8] It has been shown to directly interact with the human securin and proto-oncogene, PTTG1, thus facilitating its nuclear translocation and the subsequent transcriptional activation of basic fibroblast growth factor (bFGF) by PTTG1.[8]
Further evidence suggests that PTTG1IP may have a direct role in cancer. Initially, PTTG1IP expression was found to be higher in pituitary tumours compared with normal pituitary tissue.[9] In particular, PTTG1IP has been shown to regulate thyroid cell growth, with overexpression resulting in hyperplasia and the formation of lesions within the thyroid gland.[10] PTTG1IP expression has also been independently associated with tumour recurrence [9] and subcutaneous expression results in tumour formation in nude mice.[9]
PTTG1IP is also implicated in breast cancer.[11] Immunohistochemical analysis of tissue samples has revealed that PTTG1IP is strongly expressed in several types and grades of breast cancer.[11] Furthermore, overexpression and secretion of PTTG1IP induces cell invasion,[11] a process that is essential for the formation of metastatic disease.
Furthermore, PTTG1IP has been reported to regulate the expression of the human
Interactions
PTTG1IP has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183255 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009291 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9570958.
- PMID 10830953.
- ^ "Entrez Gene: PTTG1IP pituitary tumor-transforming 1 interacting protein".
- ^ PMID 10781616.
- ^ PMID 15886233.
- ^ PMID 21844185.
- ^ PMID 20406982.
- ^ S2CID 21358997.
- PMID 19706688.
- PMID 21450804.
- PMID 22535767.
Further reading
- Boelaert K, Tannahill LA, Bulmer JN, et al. (2003). "A potential role for PTTG/securin in the developing human fetal brain". FASEB J. 17 (12): 1631–9. S2CID 17496247.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Tfelt-Hansen J, Yano S, Bandyopadhyay S, et al. (2004). "Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells". Endocrinology. 145 (9): 4222–31. PMID 15178645.
- Stock M, Schäfer H, Fliegauf M, Otto F (2005). "Identification of novel genes of the bone-specific transcription factor Runx2". J. Bone Miner. Res. 19 (6): 959–72. S2CID 83635568.
- Boelaert K, Smith VE, Stratford AL, et al. (2007). "PTTG and PBF repress the human sodium iodide symporter". Oncogene. 26 (30): 4344–56. S2CID 21358997.
 | This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it. |