Patrick S. Moore
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Patrick Moore | |
|---|---|
Passano Award (2017) Paul Ehrlich and Ludwig Darmstaedter Prize (2017) Clarivate Citation Laureates (2017) | |
| Scientific career | |
| Fields | Cancer, Microbiology, Epidemiology |
| Institutions | UPMC Hillman Cancer Center University of Pittsburgh |
Patrick S. Moore (born October 21, 1956) is an
Merkel cell carcinoma
. Moore and Chang have discovered two of the seven known human viruses causing cancer. The couple met while in medical school together and were married in 1989 while they pursued fellowships at different universities.
Education and career
Moore received a
Operation Restore Hope.[5]
He received the 1989 CDC Langmuir Prize for his work on epidemic meningitis control.
After leaving the CDC, Moore served briefly as a New York City epidemiologist but quit to search for new human viruses with his wife,
Merkel carcinoma cells in 2008.[16] This virus causes of 50-80% of Merkel cell carcinomas[17] and hence is named Merkel cell polyomavirus. His laboratory currently seeks to understand the role of tumor virus immunoevasion of the innate immune system as a cause for viral tumorigenesis.[18][19][20][21] They have also discovered another polyomavirus (Human polyomavirus 7) as a cause of skin disease in transplant patients,[22] the generation of viral circular RNAs in KSHV, EBV and MCV,[23] the role of CDK1 in controlling protein translation during mitosis[24] and they defined the clonal mutation pattern of Merkel cell polyomavirus in cancers[25] as well as its oncogenes.[26]
Awards
- Moore and Chang are American Cancer Society Research Professors and have been awarded the 1997 Robert Koch Prize, the 2003 General Motors Cancer Research Foundation Charles S. Mott Prize,[27] the 2017 Paul Ehrlich and Ludwig Darmstaedter Prize and the 2017 Passano Foundation Passano Award. They are 2017 Clarivate Citation Laureates.
References
- PMID 1554841.
- PMID 7997865.
- PMID 1448038.
- S2CID 38013442.
- On This Day. BBC. December 9, 1992. Retrieved July 21, 2009.
- PMID 18398088.
- S2CID 29977325.
- PMID 7700311.
- PMID 9403701.
- JSTOR 3978785.
- PMID 8962146.
- S2CID 29713179.
- PMID 8523568.
- PMID 8657239.
- PMID 17686852.
- PMID 18202256.
- PMID 29072302.
- PMID 9594662.
- S2CID 23133493.
- PMID 14527293.
- PMID 21102637.
- PMID 25231015.
- PMID 30150410.
- PMID 25883264.
- PMID 18812503.
- doi:10.32388/iwhh3w
- ^ Spice, Byron (June 10, 2003). "Pitt couple wins top prize for cancer research". Pittsburgh Post-Gazette. Retrieved July 21, 2009.
Further reading
- Schmidt C (April 2008). "Yuan Chang and Patrick Moore: teaming up to hunt down cancer-causing viruses". Journal of the National Cancer Institute. 100 (8): 524–5, 529. PMID 18398088.
- Chang Y, Cesarman E, Pessin MS, et al. (December 1994). "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma". Science. 266 (5192): 1865–9. S2CID 29977325.
- Moore PS, Chang Y (May 1995). "Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection". The New England Journal of Medicine. 332 (18): 1181–5. PMID 7700310.
- Moore PS, Marfin AA, Quenemoen LE, et al. (April 1993). "Mortality rates in displaced and resident populations of central Somalia during 1992 famine". Lancet. 341 (8850): 935–8. S2CID 38013442.
- Russo JJ, Bohenzky RA, Chien MC, et al. (December 1996). "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14862–7. PMID 8962146.
- Moore PS, Broome CV (November 1994). "Cerebrospinal meningitis epidemics". Scientific American. 271 (5): 38–45. PMID 7997865.
External links
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