Pyruvate decarboxylation

Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate

Energy-generating ions and molecules, such as amino acids and carbohydrates, enter the Krebs cycle as acetyl coenzyme A and oxidize in the cycle.^[5] The pyruvate dehydrogenase complex (PDC) catalyzes the decarboxylation of pyruvate, resulting in the synthesis of acetyl-CoA, CO₂, and NADH. In eukaryotes, this enzyme complex regulates pyruvate metabolism, and ensures homeostasis of glucose during absorptive and post-absorptive state metabolism.^[6] As the Krebs cycle occurs in the mitochondrial matrix, the pyruvate generated during glycolysis in the cytosol is transported across the inner mitochondrial membrane by a pyruvate carrier under aerobic conditions.^{[citation needed]}

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