RGS20
RGS20 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process | |||
Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 8: 53.85 – 53.96 Mb | Chr 1: 4.98 – 5.14 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[5][6][7]
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][7]
In
Interactions
RGS20 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147509 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002459 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9748279.
- PMID 9748280.
- ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20".
- S2CID 24698373.
- PMID 18407463.
- PMID 12414994.
Further reading
- Barker SA, Wang J, Sierra DA, Ross EM (December 2001). "RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20". Genomics. 78 (3): 223–9. PMID 11735229.
- Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. S2CID 16065132.
- Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". The Journal of Biological Chemistry. 277 (20): 18127–33. PMID 11882662.
- Wang Y, Ho G, Zhang JJ, Nieuwenhuijsen B, Edris W, Chanda PK, Young KH (December 2002). "Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling". The Journal of Biological Chemistry. 277 (50): 48325–32. PMID 12379657.
- Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. PMID 12414994.
- Fischer T, De Vries L, Meerloo T, Farquhar MG (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8270–5. PMID 12826607.
- Xu GY, Hum WT, Sukits SF, Hsiao CL, Liu Y, Malakian K, et al. (April 2004). "1H, 13C and 15N resonance assignments of human RGSZ1". Journal of Biomolecular NMR. 28 (4): 409–10. S2CID 45949960.
- Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH (April 2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cellular Signalling. 19 (4): 723–30. PMID 17126529.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. PMID 17353931.