RU-56187

RU-56187
Clinical data
Drug class	Nonsteroidal antiandrogen
Identifiers
	IUPAC name 2-(Trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzonitrile;
JSmol)	Interactive image;
	SMILES CC1(C(=O)N(C(=S)N1C)C2=CC(=C(C=C2)C#N)C(F)(F)F)C;
	InChI InChI=1S/C14H12F3N3OS/c1-13(2)11(21)20(12(22)19(13)3)9-5-4-8(7-18)10(6-9)14(15,16)17/h4-6H,1-3H3; Key:HLBUAKQNKJTEIU-UHFFFAOYSA-N;

RU-56187 is a

silent antagonist of the androgen receptor.^[5] RU-56187 is 3- to 10-fold more potent as an antiandrogen than bicalutamide or nilutamide in animals.^[1] Both RU-56187 and RU-58841 appear to be prodrugs of cyanonilutamide (RU-56279) in vivo in animals.^[3]