SH3GLB1
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RefSeq (protein) |
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Location (UCSC) | Chr 1: 86.7 – 86.75 Mb | Chr 3: 144.39 – 144.43 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene.[5][6][7] Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 (BAR) family of proteins and plays a critical role in mitochondrial fission and fusion, as well as in autophagy and apoptosis.[8][9][10] Loss of functional endophilin-B1 is seen in many different forms of cancer.[11][12][13] The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.
Structure
In the presence of model biological membranes, endophilin-B1 dimers assemble into helical scaffolds around the membrane and drive its tubulation.[14]
Interactions
In addition to the membrane binding and remodeling properties endophilin-B1 shares with many other BAR proteins, endophilin-B1
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000097033 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037062 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 11161816.
- ^ PMID 11259440.
- ^ "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1".
- PMID 17891140.
- PMID 15452144.
- PMID 16227588.
- PMID 18833585.
- PMID 18824435.
- PMID 21283040.
- ^ S2CID 224821920.
- PMID 32881101.
- PMID 25179078.
- PMID 12456676.
Further reading
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, et al. (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–349. PMID 9455484.
- Howard L, Nelson KK, Maciewicz RA, Blobel CP (October 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". The Journal of Biological Chemistry. 274 (44): 31693–31699. PMID 10531379.
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–713. PMID 10810093.
- Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (February 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". The Journal of Biological Chemistry. 278 (6): 4160–4167. PMID 12456676.
- Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P (January 2004). "Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses". Proceedings of the National Academy of Sciences of the United States of America. 101 (2): 546–551. PMID 14704270.
- Karbowski M, Jeong SY, Youle RJ (September 2004). "Endophilin B1 is required for the maintenance of mitochondrial morphology". The Journal of Cell Biology. 166 (7): 1027–1039. PMID 15452144.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. S2CID 4427026.
- Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, et al. (November 2005). "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis". Molecular and Cellular Biology. 25 (21): 9369–9382. PMID 16227588.
- Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N (June 2006). "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms". The EMBO Journal. 25 (12): 2889–2897. PMID 16763557.
- Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH (August 2006). "Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas". Pathology. 38 (4): 312–315. S2CID 25210386.