SOAT2
SOAT2 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 12: 53.1 – 53.12 Mb | Chr 15: 102.06 – 102.07 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.[5]
Function
This gene is a member of a small family of
alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167780 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023045 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SOAT2 sterol O-acyltransferase 2".
Further reading
- Chang TY, Chang CC, Cheng D; Chang (1997). "Acyl-coenzyme A:cholesterol acyltransferase". Annu. Rev. Biochem. 66: 613–38. PMID 9242919.)
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: CS1 maint: multiple names: authors list (link - Yang H, Bard M, Bruner DA, et al. (1996). "Sterol esterification in yeast: a two-gene process". Science. 272 (5266): 1353–6. S2CID 45308699.
- Cases S, Novak S, Zheng YW, et al. (1998). "ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization". J. Biol. Chem. 273 (41): 26755–64. S2CID 11543738.
- Oelkers P, Behari A, Cromley D, et al. (1998). "Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes". J. Biol. Chem. 273 (41): 26765–71. S2CID 36046291.
- Chang CC, Sakashita N, Ornvold K, et al. (2000). "Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine". J. Biol. Chem. 275 (36): 28083–92. PMID 10846185.
- Lee H, Choi E, Seomun Y, et al. (2001). "High-Resolution Transcript Map of the Region Spanning D12S1629 and D12S312 at Chromosome 12q13: Triple A Syndrome-Linked Region". Genome Res. 10 (10): 1561–7. PMID 11042153.
- Joyce CW, Shelness GS, Davis MA, et al. (2001). "ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity to Opposite Sides of the Endoplasmic Reticulum Membrane". Mol. Biol. Cell. 11 (11): 3675–87. PMID 11071899.
- Seo T, Oelkers PM, Giattina MR, et al. (2001). "Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells". Biochemistry. 40 (15): 4756–62. PMID 11294643.
- Katsuren K, Tamura T, Arashiro R, et al. (2001). "Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia". Biochim. Biophys. Acta. 1531 (3): 230–40. PMID 11325614.
- Song BL, Qi W, Yang XY, et al. (2001). "Organization of human ACAT-2 gene and its cell-type-specific promoter activity". Biochem. Biophys. Res. Commun. 282 (2): 580–8. PMID 11401500.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Katsuren K; Fukuyama S; Takata K; Ohta T (2003). "Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia". J. Atheroscler. Thromb. 10 (1): 32–6. PMID 12621162.
- Lin S; Lu X; Chang CC; Chang TY (2004). "Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location". Mol. Biol. Cell. 14 (6): 2447–60. PMID 12808042.
- Sakashita N, Miyazaki A, Chang CC, et al. (2003). "Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies". Lab. Invest. 83 (11): 1569–81. S2CID 23331466.
- Smith JL, Rangaraj K, Simpson R, et al. (2004). "Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR". J. Lipid Res. 45 (4): 686–96. PMID 14729857.
- Liang JJ, Oelkers P, Guo C, et al. (2004). "Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells". J. Biol. Chem. 279 (43): 44938–44. S2CID 35044397.
- Parini P, Davis M, Lada AT, et al. (2005). "ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver". Circulation. 110 (14): 2017–23. S2CID 6338679.
- Kim J; Bhinge AA; Morgan XC; Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. S2CID 6135437.
- Pramfalk C, Davis MA, Eriksson M, et al. (2005). "Control of ACAT2 liver expression by HNF1". J. Lipid Res. 46 (9): 1868–76. S2CID 21852000.