Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4gene.[3][4]
Function
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the
IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.[4]
Wang CY, Podolsky R, She JX (Oct 2006). "Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene". Annals of the New York Academy of Sciences. 1079 (1): 257–67.
Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics. 36 (8): 837–41.
Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA (Feb 2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nature Genetics. 37 (2): 110–1, author reply 112–3.
Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM (Nov 2005). "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation". Biochemical and Biophysical Research Communications. 337 (2): 517–20.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18.
Costas J, Perez-Pampin E, Ferreiros-Vidal I, Torres M, Phillips C, Vicario JL, Pablos JL, Carracedo A, Gomez-Reino JJ, Gonzalez A (Jun 2006). "SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis". The Journal of Rheumatology. 33 (6): 1048–51.
Sedimbi SK, Shastry A, Park Y, Rumba I, Sanjeevi CB (Oct 2006). "Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients". Annals of the New York Academy of Sciences. 1079 (1): 273–7.
Sedimbi SK, Kanungo A, Shastry A, Park Y, Sanjeevi CB (Apr 2007). "No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients". International Journal of Immunogenetics. 34 (2): 137–42.
Bohren KM, Gabbay KH, Owerbach D (Aug 2007). "Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin". Protein Expression and Purification. 54 (2): 289–94.