IκBα
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| Location (UCSC) | Chr 14: 35.4 – 35.4 Mb | Chr 12: 55.54 – 55.54 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the
nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.[5] In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.[6]
Disease linkage
The gene encoding the IκBα protein is mutated in some
Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.[7]
Interactions
IκBα has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100906 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021025 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 7003353.
- PMID 7590248.
- S2CID 8269256.
- PMID 10644755.
- ^ PMID 9990853.
- ^ "Molecular Interaction Database". Archived from the original on 2006-05-06. Retrieved 2012-05-08.
- ^ S2CID 4327300.
- ^ PMID 9346485.
- S2CID 4354442.
- S2CID 4421236.
- PMID 9372968.
- PMID 10969074.
- ^ PMID 11313474.
- PMID 9891086.
- ^ PMID 9738011.
- PMID 11799106.
- S2CID 45796404.
- PMID 12419806.
- PMID 8139561.
- PMID 9214631.
- S2CID 41123857.
- PMID 9452483.
Further reading
- Roulston A, Lin R, Beauparlant P, Wainberg MA, Hiscott J (1995). "Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors". Microbiol. Rev. 59 (3): 481–505. PMID 7565415.
- Hay RT, Vuillard L, Desterro JM, Rodriguez MS (2000). "Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha". Philos. Trans. R. Soc. Lond. B Biol. Sci. 354 (1389): 1601–9. PMID 10582246.
- Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (2004). "HIV-1 Vpr and anti-inflammatory activity". DNA Cell Biol. 23 (4): 239–47. PMID 15142381.
- Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. PMID 15389589.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2 (1): 11. PMID 15725353.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Sun XF, Zhang H (2007). "NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases". Histol. Histopathol. 22 (12): 1387–98. PMID 17701919.
External links
- OMIM entries on Ectodermal Dysplasia, Anhidrotic, with T-cell Immunodeficiency
- NFKBIA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NF-kappaB+inhibitor+alpha at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P25963 (NF-kappa-B inhibitor alpha) at the PDBe-KB.
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