Secretory protein
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A secretory protein is any protein, whether it be
Production
The production of a secretory protein starts like any other protein. The
Modification
After the production of the protein is completed, it interacts with several other proteins to gain its final state.
Endoplasmic reticulum
After translation, proteins within the ER make sure that the protein is folded correctly. If after a first attempt the folding is unsuccessful, a second folding is attempted. If this fails too the protein is exported to the cytosol and labelled for destruction. Aside from the folding, there is also a sugar chain added to the protein. After these changes, the protein is transported to the Golgi apparatus by a coated vesicle using coating protein COPII.
Golgi apparatus
In the Golgi apparatus, the sugar chains are modified by adding or removing certain sugars. The secretory protein leaves the Golgi apparatus by an uncoated vesicle.
Secretion
Membrane proteins with functional areas on the cytosolic side of both the vesicle and cell membrane make sure the vesicle associates with the membrane. The vesicle membrane fuses with the cell membrane and so the protein leaves the cell. Some vesicles don't fuse immediately and await a signal before starting the fusing. This is seen in vesicles carrying
- Effective, database (2010)
- UniProt contains manually curated secretory proteins. There are also computationally predicted secretory protein databases, these databases are listed in the secretome section.
See also
- Bacterial outer membrane vesicles
- Exocytosis
- Host–pathogen interaction
- Membrane vesicle trafficking
- Secretion
- Secretome
- Secretomics
References
- ISBN 978-0-7167-3706-3.
External links
- "Localization: Secreted". Orientations of Proteins in Membranes (OPM) database.