Small-blue-round-cell tumor
In
malignant neoplasms that have a characteristic appearance under the microscope, i.e. consisting of small round cells that stain blue on routine H&E stained
sections.
These tumors are seen more often in children than in adults. They typically represent undifferentiated cells. The predominance of blue staining is because the cells consist predominantly of nucleus, thus they have scant cytoplasm.[1][2]
Examples
Tumors that belong to this group are:
- Desmoplastic small-round-cell tumour
- Ewing sarcoma/PNET[3][4]
- Neuroblastoma[3]
- Medulloblastoma
- Rhabdomyosarcoma[3]
- Synovial sarcoma
- Carcinoid tumor
- Mesothelioma
- Small cell lung cancer
- Wilms' tumour[1]
- Retinoblastoma[citation needed]
- Small-cell lymphoma[3]
- Hepatoblastoma[3]- only the anaplastic form has round blue cells, the more common fetal and embryonal types do not [5]
- Merkel cell carcinoma
- Mesenchymal chondrosarcoma
Conditions mimicking SBRCT
Endometrial stromal condensation may mimic a small-blue-round-cell tumour.
References
- ^ PMID 18613926.
- doi:10.1038/87150.
- ^ PMID 17251339.
- S2CID 49571421.
- ^ Gray W, Kocjan G. Diagnostic Cytopathology; . p.307