Sol Spiegelman

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Sol Spiegelman
University of Illinois at Urbana-Champaign, Columbia University
Doctoral studentsNorman R. Pace

Sol Spiegelman (December 14, 1914 – January 21, 1983) was an American molecular biologist. He developed the technique of nucleic acid hybridization, which helped to lay the groundwork for advances in recombinant DNA technology.[1][2][3]

Early life and education

Spiegelman was born in

cellular physiology under the supervision of H.B. Steinbach. Spiegelman joined Steinbach in his move to Washington University School of Medicine two years later, and received his PhD from that institution in 1944.[1] His graduate work focused on what was then known as enzymatic "induction" or "adaptation", now known to reflect changes in gene expression in response to environmental factors.[1] He continued to work at Washington University until 1948, and then took a one-year Public Health Service fellowship at the University of Minnesota.[1][3]

Academic career

In 1949, Spiegelman joined the faculty at the

Spiegelman's Monster.[1][2] Among his best-known work is his research on nucleic acid hybridization,[1] much of which was conducted in along with Kim Atwood and Ferruccio Ritossa[4] building on work by Rich and Davies in 1956,[5] which helped to lay the groundwork for advances in recombinant DNA technology.[6][1]

Spiegelman's later research focused on cancer and in 1969 he moved to the Columbia University College of Physicians and Surgeons, becoming a professor of human genetics and development as well as the directory of the Institute of Cancer Research. He was particularly interested in potential viral causes of cancer. In 1975, he was named University Professor.[1]

Awards and honors

Spiegelman received the

United States National Academy of Sciences in 1965[1][2] American Academy of Arts and Sciences a year later.[1]

Personal life

Spiegelman and his wife Helen had three children. He died of pancreatic cancer in 1983.[3]

See also

  • Spiegelman Monster

References

  1. ^ a b c d e f g h i j k l m n "The Sol Spiegelman Papers: Biographical Overview". Profiles in Science. US National Library of Medicine. March 12, 2019. Retrieved January 18, 2021.
  2. ^ a b c "Sol Spiegelman". Member Directory. National Academy of Sciences. Retrieved January 18, 2021.
  3. ^ a b c d e Webster, Bayard (January 22, 1983). "DR. SOL SPIEGELMAN, MICROBIOLOGIST AT COLUMBIA AND GENETICIST, DIES". The New York Times. p. 16. Retrieved January 18, 2021.
  4. ^ Kornberg, Hans (October 22, 1992). "Obituary: Kimball C. Atwood III". The Independent.
  5. doi:10.1021/ja01595a086
    .
  6. PMID 4955314
    .

External links

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