Spin–lattice relaxation

During nuclear magnetic resonance observations, spin–lattice relaxation is the mechanism by which the longitudinal component of the total nuclear magnetic moment vector (parallel to the constant magnetic field) exponentially relaxes from a higher energy, non-equilibrium state to thermodynamic equilibrium with its surroundings (the "lattice"). It is characterized by the spin–lattice relaxation time, a time constant known as T₁.

There is a different parameter, T₂, the

T₁ characterizes the rate at which the longitudinal M_z component of the magnetization vector recovers exponentially towards its thermodynamic equilibrium, according to equation

$${\displaystyle M_{z}(t)=M_{z,\mathrm {eq} }-\left[M_{z,\mathrm {eq} }-M_{z}(0)\right]e^{-t/T_{1}}}$$

${\displaystyle M_{z}(0)=-M_{z,\mathrm {eq} }}$

$${\displaystyle M_{z}(t)=M_{z,\mathrm {eq} }\left(1-2e^{-t/T_{1}}\right)}$$

It is thus the time it takes for the longitudinal magnetization to recover approximately 63% [1-(1/e)] of its initial value after being flipped into the magnetic transverse plane by a 90° radiofrequency pulse.

Nuclei are contained within a molecular structure, and are in constant vibrational and rotational motion, creating a complex magnetic field. The magnetic field caused by thermal motion of nuclei within the lattice is called the lattice field. The lattice field of a nucleus in a lower energy state can interact with nuclei in a higher energy state, causing the energy of the higher energy state to distribute itself between the two nuclei. Therefore, the energy gained by nuclei from the RF pulse is dissipated as increased vibration and rotation within the lattice, which can slightly increase the temperature of the sample. The name spin-lattice relaxation refers to the process in which the spins give the energy they obtained from the RF pulse back to the surrounding lattice, thereby restoring their equilibrium state. The same process occurs after the spin energy has been altered by a change of the surrounding static magnetic field (e.g. pre-polarization by or insertion into high magnetic field) or if the nonequilibrium state has been achieved by other means (e.g., hyperpolarization by optical pumping).^{[citation needed]}

The relaxation time, T₁ (the average lifetime of nuclei in the higher energy state) is dependent on the gyromagnetic ratio of the nucleus and the mobility of the lattice. As mobility increases, the vibrational and rotational frequencies increase, making it more likely for a component of the lattice field to be able to stimulate the transition from high to low energy states. However, at extremely high mobilities, the probability decreases as the vibrational and rotational frequencies no longer correspond to the energy gap between states.

Different tissues have different T₁ values. For example, fluids have long T₁s (1500-2000 ms), and water-based tissues are in the 400-1200 ms range, while fat based tissues are in the shorter 100-150 ms range. The presence of strongly magnetic ions or particles (e.g.,

T₁ is significantly different between grey matter and white matter and is used when undertaking brain scans. A strong T₁ contrast is present between fluid and more solid anatomical structures, making T₁ contrast suitable for morphological assessment of the normal or pathological anatomy, e.g., for musculoskeletal applications.

In the rotating frame

Spin–lattice relaxation in the rotating frame is the mechanism by which M_xy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a

T_1ρ MRI is an alternative to conventional T₁ and T₂ MRI by its use of a long-duration, low-power radio frequency referred to as spin-lock (SL) pulse applied to the magnetization in the transverse plane. The magnetization is effectively spin-locked around an effective B₁ field created by the vector sum of the applied B₁ and any off-resonant component. The spin-locked magnetization will relax with a time constant T_1ρ, which is the time it takes for the magnetic resonance signal to reach 37% (1/e) of its initial value, ${\displaystyle M_{xy}(0)}$. Hence the relation: ${\displaystyle M_{xy}(t_{\rm {SL}})=M_{xy}(0)e^{-t_{\rm {SL}}/T_{1\rho }}\,}$ , where t_SL is the duration of the RF field.

Measurement

T_1ρ can be quantified (relaxometry) by curve fitting the signal expression above as a function of the duration of the spin-lock pulse while the amplitude of spin-lock pulse (γB₁~0.1-few kHz) is fixed. Quantitative T_1ρ MRI relaxation maps reflect the biochemical composition of tissues.^[3]

Imaging

T_1ρ MRI has been used to image tissues such as cartilage,^[4][5] intervertebral discs,^[6] brain,^[7][8] and heart,^[9] as well as certain types of cancers.^[10][11]

See also

• Relaxation (NMR)
• Spin-spin relaxation time
• Ernst angle

References