Susan Lindquist
Susan Lindquist | |
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Born | Susan Lee Lindquist June 5, 1949 Chicago, Illinois, U.S. |
Died | October 27, 2016 Boston, Massachusetts, U.S. | (aged 67)
Nationality | American |
Alma mater |
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Known for | heat-shock proteins prions |
Awards |
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Scientific career | |
Fields | Molecular biology |
Institutions | |
Thesis | Protein and RNA synthesis induced by heat treatment in Drosophila melanogaster tissue culture cells (1976) |
Doctoral advisor | Matthew Meselson[3] |
Website | lindquistlab |
Susan Lee Lindquist,
Early life and education
Lindquist was born in Chicago, Illinois, to Iver and Eleanor (née Maggio), and attended Maine South High School in Park Ridge.[13]
Lindquist's father and mother were of Swedish and Italian descent, respectively,
Career
Upon completing her dissertation in 1976, Lindquist moved to the
In 2004, Lindquist resumed research as an Institute Member, an associate member of the
Lindquist was awarded the National Medal of Science in 2009 (presented in 2010), for research contributions to protein folding.[21]
Lindquist lectured nationally and internationally on a variety of scientific topics. In June 2006, she was the inaugural guest on the "Futures in Biotech" podcast on
Lindquist also co-founded two companies to translate research into potential therapies, FoldRx in and Yumanity Therapeutics in, companies developing drug therapies for diseases of protein misfolding and amyloidosis.[24][25]
In November 2016, Johnson & Johnson gave a $5 million gift to Whitehead Institute to establish the Susan Lindquist Chair for Women in Science in Lindquist's memory. The gift will be awarded to a female scientist at Whitehead Institute.[26]
Research
Lindquist is best known for her research that provided strong evidence for a new paradigm in
What do "mad cows", people with neurodegenerative diseases, and an unusual type of inheritance in yeast have in common? They are all experiencing the consequences of misfolded proteins. ... In humans the consequences can be deadly, leading to such devastating illnesses as Alzheimer's Disease. In one case, the misfolded protein is not only deadly to the unfortunate individual in which it has appeared, but it can apparently be passed from one individual to another under special circumstances – producing infectious neurodegenerative diseases such as mad-cow disease in cattle and Creutzfeldt–Jacob Disease in humans.[27]
Lindquist worked on the PSI+ element in yeast (a
Most of these variations are likely to be harmful, but a few unusual combinations may produce valuable new traits, spurring the pace of evolution. Cancer cells too have an extraordinary ability to evolve. Lindquist's lab investigates closely related evolutionary mechanisms involved in the progression of cancerous tumors[29] and in the evolution of antibiotic-resistant fungi.[30]
Lindquist made advances in nanotechnology, researching organic amyloid fibers capable of self-organizing into structures smaller than manufactured materials. Her group also developed a yeast "living test tube" model to study protein folding transitions in neurodegenerative diseases and to test therapeutic strategies through high-throughput screening.[31]
Publications
- Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S (2013). "Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons". Science. 342 (6161): 979–83. PMID 24158909.
- Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S (2013). "Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons". Science. 342 (6161): 983–7. PMID 24158904.
- Jarosz, D. F.; Lindquist, S. (2010). "Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation" (PDF). Science. 330 (6012): 1820–1824. PMID 21205668.
- Alberti, S.; Halfmann, R.; King, O.; Kapila, A.; Lindquist, S. (2009). "A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins". Cell. 137 (1): 146–158. PMID 19345193..
- Gitler, A. D.; Chesi, A.; Geddie, M. L.; Strathearn, K. E.; Hamamichi, S.; Hill, K. J.; Caldwell, K. A.; Caldwell, G. A.; Cooper, A. A.; Rochet, J. C.; Lindquist, S. (2009). "Α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity". Nature Genetics. 41 (3): 308–315. PMID 19182805.
- Dai, C.; Whitesell, L.; Rogers, A. B.; Lindquist, S. (2007). "Heat Shock Factor 1 is a Powerful Multifaceted Modifier of Carcinogenesis". Cell. 130 (6): 1005–1018. PMID 17889646.
- Cooper, A. A.; Gitler, A.; Cashikar, A.; Haynes, C.; Hill, K.; Bhullar, B.; Liu, K.; Xu, K.; Strathearn, K.; Liu, F.; Cao, S.; Caldwell, K. A.; Caldwell, G. A.; Marsischky, G.; Kolodner, R. D.; Labaer, J.; Rochet, J. C.; Bonini, N. M.; Lindquist, S. (2006). "-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models". Science. 313 (5785): 324–328. PMID 16794039.
- Cowen, L. E.; Lindquist, S. (2005). "Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi". Science. 309 (5744): 2185–2189. S2CID 52847795.
- Krishnan, R.; Lindquist, S. L. (2005). "Structural insights into a yeast prion illuminate nucleation and strain diversity". Nature. 435 (7043): 765–772. PMID 15944694.
- Si, K.; Lindquist, S.; Kandel, E. (2003). "A neuronal isoform of the aplysia CPEB has prion-like properties". Cell. 115 (7): 879–891. S2CID 3060439.
- Queitsch, C.; Sangster, T. A.; Lindquist, S. (2002). "Hsp90 as a capacitor of phenotypic variation". Nature. 417 (6889): 618–624. S2CID 4419085.
- Serio, T.; Cashikar, A.; Kowal, A.; Sawicki, G.; Moslehi, J.; Serpell, L.; Arnsdorf, M.; Lindquist, S. (2000). "Nucleated conformational conversion and the replication of conformational information by a prion determinant". Science. 289 (5483): 1317–1321. PMID 10958771.
- Patino, M. M.; Liu, J. -J.; Glover, J. R.; Lindquist, S. (1996). "Support for the Prion Hypothesis for Inheritance of a Phenotypic Trait in Yeast". Science. 273 (5275): 622–626. S2CID 9760894.
- Lindquist, S. (1981). "Regulation of protein synthesis during heat shock". Nature. 293 (5830): 311–314. S2CID 4263197.
Awards and honors
Lindquist won numerous awards and honors including:
- Elected to the American Academy of Arts and Sciences in 1996.[13]
- Elected to the National Academy of Sciences in 1997.[13]
- Named a fellow of the American Academy of Microbiology in 1997.[32]
- Received the Novartis/Drew Award in Biomedical Research in 2000.[18]
- Received the Dickson Prize in Medicine in 2003.[33]
- Elected to the American Philosophical Society in 2003.[34]
- Named one of the 50 most important women in science by Discover Magazine in 2002.[35]
- Awarded the Sigma Xi William Procter Prize for Scientific Achievement in 2006.[36]
- Elected to the Institute of Medicine of the National Academies in 2006.[36]
- Awarded the Genetics Society of America Medal in 2008.[1]
- Awarded the Otto Warburg Medal by the German Society for Biochemistry and Molecular Biology in 2008.[37]
- Awarded the FASEB Excellence in Science Award in 2009.[17]
- Awarded the Max Delbrück Medal, Berlin, Germany, in 2010.[38]
- Awarded the Mendel Medal by The Genetics Society, UK, in 2010.[39]
- Awarded the National Medal of Science (for 2009) in 2010.[40]
- Made an Associate Member of the European Molecular Biology Organization in 2011.[41]
- Awarded the The American Society for Cell Biology in 2012.[42]
- Awarded the Vanderbilt University School of Medicine Vanderbilt Prize for Women's Excellence in Science and Mentorship in 2014.[43]
- Elected a
- Vallee Visiting Professorship (2015)[45]
- Awarded the Albany Medical Center Prize in Medicine and Biomedical Research with F. Ulrich Hartl and Arthur Horwich in 2016.[31]
- Awarded (posthumously) the Rosenstiel Award in 2016.[46]
Personal life
Lindquist was married to Edward Buckbee and had two daughters.[20] She died of cancer in Boston at the age of 67 on October 27, 2016.[47][9]
References
- ^ PMID 18385104.
- ^ a b "Susan Lindquist". Royal Society. Retrieved October 30, 2016.
- ^ PMID 21589898.
- ^ "Whitehead Institute – Faculty". Whitehead.mit.edu. Retrieved October 30, 2016.
- ^ "Lindquist Lab | Lindquist Lab at the Whitehead Institute for Biomedical Research | Lindquist Lab". mit.edu. February 10, 2016. Archived from the original on July 16, 2012. Retrieved October 30, 2016.
- PMID 19048046.
- S2CID 42450279.
- S2CID 31351089.
- ^ S2CID 5375718.
- ^ "Prions and Protein Folding: Video talk by Dr. Susan Lindquist". Ibiology.org. June 16, 2015. Archived from the original on October 29, 2016. Retrieved October 30, 2016.
- ^ "Whitehead Institute – Faculty". mit.edu. Retrieved October 30, 2016.
- ^ "Susan Lindquist – 2009 National Medal of Science". YouTube. November 29, 2010. Archived from the original on December 11, 2021. Retrieved October 30, 2016.
- ^ ISSN 0362-4331. Retrieved October 30, 2016.
- ^ Fleischman, John (October 28, 2016). "In Memoriam: Susan Lindquist, 67, Pioneer in Protein Folding Research – ASCB". ASCB Post. Archived from the original on November 3, 2016.
- PMID 21589898.
- OCLC 14767508.
- ^ a b c "FASEB ANNOUNCES RECIPIENT OF THE 2009 EXCELLENCE IN SCIENCE AWARD" (PDF). Federation of American Societies for Experimental Biology. July 18, 2008. Archived from the original (PDF) on June 30, 2014. Retrieved October 31, 2016.
- ^ PMID 29413691.
- ^ "Susan Lindquist, PhD". HHMI.org. Retrieved October 30, 2016.
- ^ a b "Whitehead Institute – News – 2016 – Susan Lindquist, accomplished and beloved scientist, has died at age 67". wi.mit.edu. Retrieved October 28, 2016.
- ^ "The President's National Medal of Science: Recipient Details | NSF – National Science Foundation". www.nsf.gov. Retrieved August 7, 2018.
- ^ "Futures in Biotech 1 Dr. Susan Lindquist | TWiT.TV". TWiT.tv. Retrieved October 31, 2016.
- ^ Yossi Sheffi. "MIT and the World Economic Forum". mit.edu. Retrieved October 30, 2016.
- ^ "Scientific Founders – FoldRx". Archived from the original on July 11, 2011. Retrieved October 31, 2016.
- ^ "Yumanity Therapeutics". www.yumanity.com. Retrieved July 2, 2017.
- ^ WEISMAN, ROBERT (November 17, 2016). "A chair at MIT in Lindquist's memory". Boston Globe. Retrieved September 21, 2017.
- ^ "From Mad Cows to 'Psi-chotic' Yeast: A New Paradigm in Genetics", NAS Distinguished Leaders in Science Lecture Series, November 10, 1999.
- MIT Biology. Archived from the originalon October 30, 2016. Retrieved October 30, 2016.
- ^ "Whitehead Institute – News – 2014 – Master heat-shock factor supports reprogramming of normal cells to enable tumor growth and metastasis". wi.mit.edu. July 31, 2014. Retrieved October 31, 2016.
- S2CID 27186932.
- ^ a b "Whitehead Institute – News – 2016 – Whitehead's Susan Lindquist to receive prestigious Albany Prize in Medicine". wi.mit.edu. Retrieved October 31, 2016.
- ^ "Navigation for iFrame". accounts.asm.org. Retrieved October 31, 2016.
- ^ Webteam, University of Pittsburgh University Marketing Communications. "Susan L. Lindquist, PhD | Dickson Prize in Medicine". www.dicksonprize.pitt.edu. Retrieved October 30, 2016.
- ^ "Susan Lindquist, pioneering biologist and former director of Whitehead Institute, dies at 67 Biology professor and mentor to many investigated protein folding and its role in disease". MIT News. October 28, 2016. Retrieved May 1, 2019.
- ^ Svitil, Kathy (November 13, 2002). "The 50 Most Important Women in Science". Discover. Retrieved May 1, 2019.
- ^ a b "Susan L. Lindquist profile". jnj.com. Retrieved October 31, 2016.
- ^ "U.S. Scientist Receives Otto Warburg Medal Sponsored By QIAGEN". www.abnnewswire.net. Retrieved October 31, 2016.
- ^ "Professor Susan Lindquist from the Whitehead Institute Receives Max Delbrück Medal in Berlin". Mdc-berlin.de. Archived from the original on January 3, 2011. Retrieved October 30, 2016.
- ^ "2010 Mendel Lecture – The Genetics Society". Archived from the original on August 13, 2011. Retrieved October 31, 2016.
- ^ Valverde, Miriam (November 18, 2010). "Cambridge researcher honored at White House". The Boston Globe.
- ^ "Recipients of European Molecular Biology Organization Associate Member award". biology.mit.edu. Archived from the original on October 30, 2016. Retrieved October 30, 2016.
- ^ "Recipients of American Society for Cell Biology E.B. Wilson Medal award | MIT Biology". biology.mit.edu. Archived from the original on October 30, 2016. Retrieved October 30, 2016.
- ^ "Recipients of Vanderbilt University School of Medicine Vanderbilt Prize for Women's Excellence in Science and Mentorship award". biology.mit.edu. Archived from the original on October 30, 2016. Retrieved October 30, 2016.
- ^ "Fellows Directory". Royal Society. Retrieved October 30, 2016.
- ^ "2015 Vallee Visiting Professors Announced". The Vallee Foundation. 2014. Retrieved May 1, 2019.
- ^ "Current Winner – Rosenstiel Award – Rosenstiel Basic Medical Sciences Research Center – Brandeis University". www.brandeis.edu.
- ^ Grimes, William (October 29, 2016). "Susan Lindquist Scientist Who Made Genetic Discoveries Using Yeast Dies at 67". The New York Times. Retrieved October 30, 2016.