Synairgen

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Synairgen PLC
AIM: SNG
IndustryDrug discovery
Biotechnology
Founded2003 (2003)[1]
Founder
Headquarters
Southampton
,
United Kingdom
Key people
  • Richard Marsden (CEO)
  • John Ward (CFO)
  • Phillip Monk (CSO)
Websitesynairgen.com

Synairgen is a

COVID-19.[5][6][7][8][9]

Richard Marsden was appointed chief executive officer in September 2009.[10]

Business Activities

Synairgen has developed and is testing an inhaled formulation of interferon beta, a naturally occurring protein which orchestrates the body's antiviral responses. Viruses, including coronaviruses, have evolved mechanisms which suppress natural IFN-β production, thereby helping the virus evade the immune system.[11]

Richard Marsden, the company's chief executive, said one of the main ways viruses evaded the immune system was “to suppress the production of interferon beta”, which plays a significant role in activating the wider immune response and preventing a virus from replicating. “All we’re doing is putting . . . this protein, that everyone makes, back into the battleground, and the battleground that matters is in the lungs,” Marsden said.[12]

COVID-19 Drug Trials

In March 2020,[13] Synairgen initiated a placebo-controlled Phase 2 trial of SNG001, an inhaled form of interferon beta, in COVID-19 patients in the UK.

In July 2020, Synairgen announced SNG001 lowered the risk of severe COVID-19 in infected patients in a small clinical trial. The details of the study were published in Lancet in November 2020.[14]

The Phase 3 SPRINTER trial (SG018), a randomised, double-blind, placebo-controlled study evaluating SNG001 for the treatment of hospitalised COVID-19 patients, was initiated in January 2021.[15] It completed enrolment of 610 patients in November 2021[16] across 17 countries.  

SNG001 is also being investigated independently as part of the US National Institute of Health's ACTIV-2 (Accelerating COVID-19 Therapeutic Interventions and Vaccines) programme [17] to accelerate the development of the most promising COVID-19 treatments.  

The ACTIV-2 study, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and led by the NIAID-funded AIDS Clinical Trials Group (ACTG), is testing agents in outpatient adults with documented positive SARS-CoV-2 infection and symptoms of COVID-19.  Synairgen's SNG001 was advanced into Phase 3 in October 2021.[18]

References

  1. ^ a b Anon (2016). "SYNAIRGEN PLC". companieshouse.gov.uk. London: Companies House.
  2. ^ Anon (2020). "SYNAIRGEN PLC SNG Stock". londonstockexchange.com. London Stock Exchange.
  3. ^ Rowlatt, Justin (July 20, 2020). "Covid treatment trial described as 'breakthrough'". bbc.co.uk. BBC News.
  4. ^ "Clean Air Champion Professor Sir Stephen Holgate receives Knighthood". Clean Air Programme. 2021-12-07. Retrieved 2022-02-03.
  5. ^ "- Synairgen". synairgen.com. Retrieved 2022-02-03.
  6. ^ Neate, Rupert (July 24, 2020). "'Major' breakthrough in Covid-19 drug makes UK professors millionaires". The Guardian.
  7. ^ Anon (2020). "Expert reaction to announcement by Synairgen that their drug SNG001 has had positive results in initial trials on COVID-19 patients". Science Media Centre.
  8. Daily Telegraph
    .
  9. S2CID 8539798
    .
  10. ^ "SNG: Synairgen PLC Stock Price Quote - London - Bloomberg". bloomberg.com. Retrieved 2022-02-03.
  11. PMID 32661059
    .
  12. ^ Neville, Sarah; Asgari, Nikou (2021-09-27). "Antiviral pill: How close are we to a drug to treat Covid?". ft.com. Financial Times. Retrieved 2022-02-03.
  13. ^ "Experimental lung drug to be tested on UK coronavirus patients". The Guardian. 2020-03-18. Retrieved 2022-02-03.
  14. PMID 33189161
    .
  15. ^ Synairgen Research Ltd. (2021-11-03). "A Randomised, Double-blind, Placebo-controlled, Phase III Trial to Determine the Efficacy and Safety of Inhaled SNG001 for the Treatment of Patients Hospitalised Due to Moderate COVID-19". clinicaltrials.gov.
  16. ^ "Synairgen concludes patient enrolment for Covid-19 trial". clinicaltrialsarena.com. 2021-11-12. Retrieved 2022-02-03.
  17. ^ "COVID-19 Therapeutics Prioritized for Testing in Clinical Trials". nih.gov. National Institutes of Health. 2020-07-21. Retrieved 2022-02-03.
  18. ^ "Synairgen surges as US Covid-19 study advances to final stage trials | Shares Magazine". sharesmagazine.co.uk. Retrieved 2022-02-03.
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