TAB1
Ensembl | |||||||||
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| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 22: 39.4 – 39.44 Mb | Chr 15: 80.02 – 80.05 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene.[5][6][7]
Function
The protein encoded by this gene was identified as a regulator of the
ubiquitinated.[8]
This protein plays an important role in
oncogenesis.[13]
Interactions
TAB1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100324 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022414 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 84807994.
- PMID 10187861.
- ^ a b "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1".
- ^ "TAB1 (human)". www.phosphosite.org. Retrieved 2020-10-31.
- PMID 16675448.
- PMID 16754690.
- PMID 19419968.
- PMID 21233843.
- PMID 20959492.
- ^ PMID 10882101.
- S2CID 11683986.
- ^ PMID 14670075.
- ^ S2CID 4421236.
- PMID 12975377.
- S2CID 30831863.
- PMID 25260751.
- S2CID 93896233.
- PMID 12589052.
- PMID 11737269.
- PMID 19112497.
- PMID 9878061.
- PMID 12048196.
- S2CID 29818690.
Further reading
- Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. S2CID 29818690.
- Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway". EMBO J. 18 (1): 179–87. PMID 9878061.
- Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. S2CID 4421236.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. PMID 10591208.
- Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop". J. Biol. Chem. 275 (10): 7359–64. PMID 10702308.
- Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2–3): 141–5. S2CID 30831863.
- Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K (2001). "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK". J. Biol. Chem. 276 (26): 24396–400. PMID 11323434.
- Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B." J. Biol. Chem. 276 (45): 41661–7. PMID 11518704.
- Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7". Genes Cells. 6 (12): 1091–9. PMID 11737269.
- Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science. 295 (5558): 1291–4. S2CID 93896233.
- Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T (2002). "TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways". Biochem. Biophys. Res. Commun. 297 (5): 1277–81. PMID 12372426.
- Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J (2003). "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1". J. Biol. Chem. 278 (4): 2286–93. PMID 12429732.
- Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131–9. PMID 12482967.
- Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S (2003). "Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade". Nat. Cell Biol. 5 (3): 224–30. S2CID 114603.
- Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS (2003). "Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia". Circ. Res. 93 (3): 254–61. PMID 12829618.
- Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. PMID 12975377.
- Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. PMID 14670075.
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