TCB-2
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Routes of administration | Oral |
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TCB-2 is a
derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonist for the 5-HT2A and 5-HT2C receptors with a Ki
of 0.26 nM at the human 5-HT2A receptor.
In drug-substitution experiments in rats, TCB-2 was found to be of similar potency to both LSD and Bromo-DragonFLY, ranking it among the most potent phenethylamine hallucinogens yet discovered.[1] This high potency and selectivity has made TCB-2 useful for distinguishing 5-HT2A receptor-mediated responses from those produced by other similar receptors.[2]
TCB-2 has similar but not identical effects in animals to related phenethylamine hallucinogens such as
cocaine addiction and neuropathic pain.[3][4][5][6] It has also been found to produce rapid antidepressant-, anti-anhedonic-, and anxiolytic-like effects in animals.[7]