TFB1M
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Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.[5][6][7]
TFB1M is a mitochondrial methyltransferase, which uses
12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[6][8][9]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[10] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.[11]
Interactions
TFB1M has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000029639 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036983 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10810093.
- ^ PMID 11809803.
- ^ "Entrez Gene: TFB1M transcription factor B1, mitochondrial".
- S2CID 11164308.
- PMID 19356719.
- S2CID 11164308.
- PMID 29149603.
- PMID 12897151.
Further reading
- Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. S2CID 11164308.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Seidel-Rogol BL, McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop". Nat. Genet. 33 (1): 23–4. S2CID 169443.
- Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6. S2CID 25379746.
- McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. PMID 12897151.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. PMID 14574404.
- Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation". Mol. Genet. Metab. 82 (1): 27–32. PMID 15110318.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. PMID 15684387.
- Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Res. 35 (12): 4042–54. PMID 17557812.
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