Talk:Eucalyptol

Last edited at 03:16, 14 October 2009 (UTC). Substituted at 14:44, 29 April 2016 (UTC)

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Cough drops used to contain eucalyptus oil as.decongestant but the menthol was cough suppressant and analgesic. Reaction with water & sulfuric acid gave "Terpin Hydrate" which was the distinctive taste of traditional Codeine cough syrup. And I assume the reason for removing Eucalyptus oil from cough drops is its a common allergen. Shjacks45 (talk) 10:50, 4 July 2019 (UTC)[reply]

Here’s a citation for its presence in Melaleuca alternifolia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360273/ … sorry I don’t have time to figure out all the proper formatting just now. — AlexBayleaf 58.96.87.140 (talk) 09:28, 3 July 2022 (UTC)[reply]

The biosynthesis of eucalytol can be described concisely. Linalyl pyrophosphate, which the editor refuses to link, converts to eucalytol as mediated by an enzyme cineole synthase. Its not complicated, in fact kind of routine: linalyl pyrophosphate is a common precursor to many terpenes and terpenoids.

Like almost all terpene conversions, the synthase mediates the formation and rearragement of carbocations. That is the "magic" of terpene biosyntheses. Racemic eucalytol is produced. One editor seeks to depict the proposed pathway for each enantiomer, which is redundant and the resulting image is difficult to read. The same editors wishes to describe the excruciating details of conformational changes and the hydrolysis of the ultimate carbocation. A number terpene and terpenoid biosyntheses are described in this encyclopedia, and we rarely describe conformational manipulations by the protein because that is what enzymes do. The hydrolysis of carbo cations (R₃C⁺ + H₂O → R₃COH + H⁺ is routine. The referencing is redundant. So that is my case:

1. cropped image
2. acknowledge the role of linalyl pyrophosphate with link to linalool
3. omit or compress discussion of conformational changes
4. omit or compress description of hydrolysis of carbocation
5. simplify referencing

I have tried to engage the editor on their talk page without any response. --Smokefoot (talk) 13:28, 10 June 2023 (UTC)[reply]

I agree with Smokefoot. The version here is concise and clear, with the appropriate biosynthesis image. Zefr (talk) 14:06, 10 June 2023 (UTC)[reply]

I think that

MOS:CSDG. I'll provide my own version later. Mike Turnbull (talk) 14:36, 10 June 2023 (UTC)[reply

]

Good pt about the product being achiral. For some reason the author wanted to show the two enantiomeric precursors though.--Smokefoot (talk) 15:34, 10 June 2023 (UTC)[reply]

I've added a new diagram, which I hope everyone can agree is acceptable and shows the key parts of the mechanism. Mike Turnbull (talk) 15:49, 10 June 2023 (UTC)[reply]