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I'm pretty sure PCC is administered to warfarin patients experiencing acute bleeding even if the INR is much lower than 8. Perhaps 8.0 is the level when you'd start administration PCC even without acute bleeding? Patient comes in with acute intracranial hemorrhage, INR of 2.1, you reach for the Prothrombin complex concentrate and the INR is fixed in less than 10 minutes. You also give Vitamin K for the sustained reversal in such a case, but it won't start helping until 12-24 hours later. — Preceding unsigned comment added by 2607:FEA8:3DE0:CF8:61E4:9489:DA62:654E (talk) 01:50, 17 August 2018 (UTC)[reply]