Talk:Selective immunoglobulin A deficiency

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I found selective Ig A deficiency to be highly symptomatic indeed! It was, for me, extremely difficult to live with and left me very seriously impaired for the first 30 years of my life. I suffered ghastly allergies, ending up on Vivonex Defined Diet(synthetically made critical ingredients) for nearly a year before being cured.

When first found, at the age of about 30, i had 1 international unit of Ig A in my blood. Total food allergy, severe inhalent allergies(molds, pollens, dust), chronic sinus ear nose throat infections,total food allergy, rather crippled up with it.

Since i had 1 unit of Ig A, my immunologist used Tice Strain BCG vaccination to stimulate my cellular immune system into producing more Ig A. He first started out with 4 intradermal weals at a time. the first weals were full vaccine strength, and following ones were booster strength. At the time he had an IND from FDA for Cancer Immunology work(he caused a 30% increase in remission rates across the board in peer reviewed work, duplicated by many investigators worldwide). To this day, Tice Strain BCG Vaccine is the Gold Standard for treatment of bladder cancer.

As he had an IND, this also allowed him to use Tice Strain BCG orally. Dilute the right amount, squirt it on the tongue, chase it with a glass of water. This had the advantage of stimulating Peyer's Patches in the gut, with much improved tolerance of food.

My Ig A level went from 1 unit to 166 units and remains there 25 years later.

This certainly improved my allergy situation considerably.

I find the statement that no treatment for it exists to be in error. For babies and children below the age of puberty, the only necessary treatment for Ig A deficiency is to simply put them on a ZERO protein diet(one of the Vivonex Defined Diets was used for me, synthetically made essential amino acids plus extra high purity vitamins, minersls and ultra super refined carbohydrate from corn) for 6 months. The Ig A level rises to normal and gradual re-introduction of foods with sublingual allergen treatment of any allergies that show up. This is a CURE, i repeat CURE. Dr. David L. Morris, M. D., La Crosse, WI has published this work.

I was present in Dr. Morris office on the day a 5 month old baby was brought in, sounding like a giant bubble machine from lung congestion. The kind of situation that puts you on the edge of your chair, as the last gurgle sounded like the final one.

Immediate treatment with Adrenalin, as well as blood testing, revealed Ig A deficiency and total food allergies.

With the use of the zero protein diet, total recovery and normal Ig A level were routine. That child was so lucky to be diagnosed and treated at that age.

18 y/o female here who just recently was diagnosed with IgA deficiency and now that I know what it is, I fit the symptoms perfectly. I have had chronic ear and sinus infections since I was born, I've had three awful bouts of pneumonia, I have asthma now from the pneumonia, last year I was hospitalized for an infection of my abdominal wall and other stomach/gastro issues. Officially, I had <6 International units of IgA (my doctor said it looked like about 4) and have had no treatment officially yet. However, prior to knowing what the issue was, I was given something called Aller-C (a bioflavanoid with 1500% DV Vitamin C) and it worked wonders for allergies and asthma related issues. I would recommend it highly to anyone experiencing any of those symptoms. — Preceding unsigned comment added by Kaylengill (talk • contribs) 17:08, 8 August 2016 (UTC)[reply]

Notes from a non-medical professional who has this deficiency:

The tone of this Wikipedia definition may be accurate in the general. But I question the opening statement that this is a relatively mild genetic immunodeficiency. In my case, its onset in early middle age had profound consequences on my health, work, and personal life. I believe the potential severity of this deficiency is not adequately stressed. The definition needs be better balanced, indicating explicitly that its effects on health can range from relatively mild to severe.

The article is correct that this deficiency can be confirmed by laboratory measurement. But it should also be noted that too often it is not suspected by medical personnel and thus no blood draw is taken. I spent three years in Paris, evidencing all symptoms, and no one in that sophisticated medical community thought to look. Even now, many doctors I meet either do not know what the illness is or are surprised that it was detected. I believe this lack of awareness by the larger medical community should be given as an advisory notice.

Lastly, although there is no cure, there is treatment: regular infusions of of the synthesized blood product IVIG. This replaces to a substantial extent the IGA which the body will not allow to be produced. It is expensive (up to 4-5 thousand per) and there are often shortages. But it exists.

It would appear much of the information in this Wikipedia page dates from over a decade ago (?) Much research has been done in the meantime. Again, I am not a medical professional. But I believe this page should be marked as questionable and a request be made for revision by trained immunologists. (comments added to article 02:25, 14 February 2009 Ronaldo aran; moved to talk page --Arcadian (talk) 16:01, 14 February 2009 (UTC))[reply]

I would like to know how does secretary IgA works? If it is not complement activator and it is not opsonin because it's fc region attached to j bond then how does it works exactly...? —Preceding unsigned comment added by 208.120.201.128 (talk) 00:24, 30 October 2010 (UTC)[reply]

I reverted to text prior to a copyvio from this text. This appears to be a good secondary source, but needs to be incorporated rather than copyvio. Yobol (talk) 00:33, 21 August 2011 (UTC)[reply]

Prior content in this article duplicated one or more previously published sources. The material was copied from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821513/. Copied or closely paraphrased material has been rewritten or removed and must not be restored, unless it is duly released under a compatible license. (For more information, please see

doi:10.1111/sji.12499 JFW | T@lk 11:06, 6 December 2016 (UTC)[reply]

We say it's inherited and and it's not in the same paragraph. The only reference is offline. Secretlondon (talk) 11:30, 6 August 2017 (UTC)[reply]