Tensilon test

Tensilon test
Reversal of ptosis following tensilon test in a myasthenia gravis
Synonyms	Edrophonium test
Purpose	Diagnose neural diseases
MedlinePlus	003930

A tensilon test, also called an edrophonium test, is a pharmacological test used for the diagnosis of certain neural diseases, especially

A 10 mg edrophonium chloride syringe and a 2 mg atropine syringe are prepared. Atropine is prepared for immediate use in case cholinergic crisis occurs. After a neurologic examination and recording of vital signs, 2 mg edrophonium is injected intravenously. After waiting 30 seconds and ensuring that no adverse reactions have occurred, the remaining 8 mg of edrophonium is also injected. The patient is then asked to perform repetitive tasks, such as lifting an object or opening and closing the eyelids. Under the influence of edrophonium, patients with myasthenia gravis are able to complete these tasks more easily and with more strength than before the injection was administered. The effects of edrophonium last around ten minutes. The edrophonium allows accumulation of acetylcholine (ACh) in the neuromuscular junctions and makes more ACh available to the muscle receptors, thereby increasing muscle strength in myasthenia gravis.^[3] In newborns, a 0.15 mg/kg dose of neostigmine administered

Precautions

The tensilon test is administered by a trained clinician, usually a