Transformation/transcription domain-associated protein
| TRRAP | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
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| Location (UCSC) | Chr 7: 98.88 – 99.05 Mb | Chr 5: 144.7 – 144.8 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Transformation/transcription domain-associated protein, also known as TRRAP, is a protein that in humans is encoded by the TRRAP gene.[5][6] TRRAP belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
Function
TRRAP is an
oncoprotein that deregulates transcription of key genes.[7]
TRRAP is also required for the
RAD50, and NBS1) is involved in the detection and repair of DNA double-strand breaks (DSBs). TRRAP associates with the MRN complex and when TRRAP is removed, the complex shows reduced cDNA end-joining activity. Hence, TRRAP may function as a link between DSB repair and chromatin remodeling.[8][9]
Interactions
Transformation/transcription domain-associated protein has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196367 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045482 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 17693834.
- PMID 9885574.
- S2CID 22598445.
- PMID 16382133.
- PMID 15711126.
- ^ PMID 11839798.
- ^ S2CID 15634637.
- ^ PMID 10611234.
- ^ PMID 12660246.
- ^ PMID 11564863.
Further reading
- Herceg Z, Wang ZQ (2006). "Rendez-vous at mitosis: TRRAPed in the chromatin". Cell Cycle. 4 (3): 383–7. PMID 15711126.
- Murr R, Vaissière T, Sawan C, Shukla V, Herceg Z (2007). "Orchestration of chromatin-based processes: mind the TRRAP". Oncogene. 26 (37): 5358–72. S2CID 22598445.
- McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (1998). "The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. S2CID 17693834.
- Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell. 2 (6): 869–75. PMID 9885574.
- Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". J. Biol. Chem. 274 (26): 18285–9. PMID 10373431.
- McMahon SB, Wood MA, Cole MD (2000). "The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc". Mol. Cell. Biol. 20 (2): 556–62. PMID 10611234.
- Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y (2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis". Cell. 102 (4): 463–73. S2CID 18047169.
- Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. PMID 11406595.
- Lee YJ, Chung TS, Yoon YS, Lee MS, Han SH, Seong GJ, Ahn KJ (2001). "The role of functional MR imaging in patients with ischemia in the visual cortex". American Journal of Neuroradiology. 22 (6): 1043–9. PMID 11415895.
- Lang SE, McMahon SB, Cole MD, Hearing P (2001). "E2F transcriptional activation requires TRRAP and GCN5 cofactors". J. Biol. Chem. 276 (35): 32627–34. PMID 11418595.
- Park J, Kunjibettu S, McMahon SB, Cole MD (2001). "The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis". Genes Dev. 15 (13): 1619–24. PMID 11445536.
- Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. S2CID 15634637.
- Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. PMID 11564863.
- Park J, Wood MA, Cole MD (2002). "BAF53 Forms Distinct Nuclear Complexes and Functions as a Critical c-Myc-Interacting Nuclear Cofactor for Oncogenic Transformation". Mol. Cell. Biol. 22 (5): 1307–16. PMID 11839798.
- Yanagisawa J, Kitagawa H, Yanagida M, Wada O, Ogawa S, Nakagomi M, Oishi H, Yamamoto Y, Nagasawa H, McMahon SB, Cole MD, Tora L, Takahashi N, Kato S (2002). "Nuclear receptor function requires a TFTC-type histone acetyl transferase complex". Mol. Cell. 9 (3): 553–62. PMID 11931763.
- Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD (2002). "TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins". Mol. Cell. Biol. 22 (14): 5054–63. PMID 12077335.
- Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB (2002). "Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes". Mol. Cell. Biol. 22 (16): 5650–61. PMID 12138177.
- Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. S2CID 6035986.
- Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. 278 (22): 20405–12. PMID 12660246.