Tyrosine-protein kinase CSK
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| Location (UCSC) | Chr 15: 74.78 – 74.8 Mb | Chr 9: 57.53 – 57.56 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an
Function
This Non-receptor tyrosine-protein kinase plays an important role in the regulation of
phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is then recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane and ultimately suppresses signaling through various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several effector molecules.[6][7]
Role in development and regulation
Tyrosine-protein kinase CSK is involved in the following developmental, metabolic, and signal transduction cascades:
T cell receptor signaling pathway.[12]
Expression and subcellular location
CSK is expressed in the lungs and macrophages as well as several other tissues.[13] Tyrosine-Kinase CSK is mainly present in the cytoplasm, but also found in lipid rafts making cell-cell junction.[12]
Mutations
- Y184F – Abolishes phosphorylation.[14]
- Y304F – Decreases activity by two-thirds and alters conformation.[14]
- S364A – Strong decrease of phosphorylation by PRKACA (the catalytic subunit of protein kinase A).[15]
Clinical significance
Csk's interaction with a phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations.[16]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103653 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032312 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: C-src tyrosine kinase". Retrieved 2013-07-11.
- ^ PMID 1639064.
- ^ PMID 9281320.
- S2CID 4363527.
- S2CID 37988394.
- PMID 16959780.
- S2CID 38227036.
- ^ a b Universal protein resource accession number P41240 for "Tyrosine-protein kinase CSK" at UniProt.
- PMID 1371489.
- ^ PMID 9148770.
- PMID 11181701.
- PMID 20538612.
External links
- CSK tyrosine-protein kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
