WFIKKN1
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| Location (UCSC) | Chr 16: 0.63 – 0.63 Mb | Chr 17: 26.1 – 26.1 Mb | |||||||
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WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.[5][6][7] when found in humans.
This gene encodes a secreted multidomain protein consisting of a
immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127578 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071192 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11274388.
- S2CID 37069938.
- ^ a b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".
Further reading
- Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR. 35 (1): 73–8. S2CID 34083234.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. S2CID 27764390.
- Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. PMID 12709070.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
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