Wetware computer
A wetware computer is an
Overview
The concept of wetware is an application of specific interest to the field of computer manufacturing.
Background
The concept of wetware is distinct and unconventional and draws slight resonance with both hardware and software from conventional computers. While hardware is understood as the physical architecture of traditional computational devices, built from electrical circuitry and silicone plates, software represents the encoded architecture of storage and instructions. Wetware is a separate concept that uses the formation of organic molecules, mostly complex cellular structures (such as neurons), to create a computational device such as a computer. In wetware, the ideas of hardware and software are intertwined and interdependent. The molecular and chemical composition of the organic or biological structure would represent not only the physical structure of the wetware but also the software, being continually reprogrammed by the discrete shifts in electrical pulses and chemical concentration gradients as the molecules change their structures to communicate signals. The responsiveness of a cell, proteins, and molecules to changing conformations, both within their structures and around them, ties the idea of internal programming and external structure together in a way that is alien to the current model of conventional computer architecture.[1]
The structure of wetware represents a model where the external structure and internal programming are interdependent and unified; meaning that changes to the programming or internal communication between molecules of the device would represent a physical change in the structure. The dynamic nature of wetware borrows from the function of complex cellular structures in biological organisms. The combination of “hardware” and “software” into one dynamic, and interdependent system which uses organic molecules and complexes to create an unconventional model for computational devices is a specific example of applied biorobotics.
The cell as a model of wetware
Cells in many ways can be seen as their form of naturally occurring wetware, similar to the concept that the human brain is the preexisting model system for complex wetware. In his book Wetware: A Computer in Every Living Cell (2009) Dennis Bray explains his theory that cells, which are the most basic form of life, are just a highly complex computational structure, like a computer. To simplify one of his arguments a cell can be seen as a type of computer, using its structured architecture. In this architecture, much like a traditional computer, many smaller components operate in tandem to receive input, process the information, and compute an output. In an overly simplified, non-technical analysis, cellular function can be broken into the following components: Information and instructions for execution are stored as DNA in the cell, RNA acts as a source for distinctly encoded input, processed by ribosomes and other transcription factors to access and process the DNA and to output a protein. Bray's argument in favor of viewing cells and cellular structures as models of natural computational devices is important when considering the more applied theories of wetware to biorobotics.[1]
Biorobotics
Wetware and biorobotics are closely related concepts, which both borrow from similar overall principles. A biorobotic structure can be defined as a system modeled from a preexisting organic complex or model such as cells (neurons) or more complex structures like organs (brain) or whole organisms.[5] Unlike wetware the concept of biorobotics is not always a system composed of organic molecules, but instead could be composed of conventional material which is designed and assembled in a structure similar or derived from a biological model. Biorobotics have many applications and are used to address the challenges of conventional computer architecture. Conceptually, designing a program, robot, or computational device after a preexisting biological model such as a cell, or even a whole organism, provides the engineer or programmer the benefits of incorporating into the structure the evolutionary advantages of the model.[6]
Applications and goals
Basic neurocomputer composed of leech neurons
In 1999 William Ditto and his team of researchers at
Biological models for conventional computing
After his work creating a basic computer from leech neurons, Ditto continued to work not only with organic molecules and wetware but also on the concept of applying the chaotic nature of biological systems and organic molecules to conventional material and logic gates. Chaotic systems have advantages for generating patterns and computing higher-order functions like memory, arithmetic logic, and input/output operations.[8] In his article Construction of a Chaotic Computer Chip Ditto discusses the advantages in programming of using chaotic systems, with their greater sensitivity to respond and reconfigure logic gates in his conceptual chaotic chip. The main difference between a chaotic computer chip and a conventional computer chip is the reconfigurability of the chaotic system. Unlike a traditional computer chip, where a programmable gate array element must be reconfigured through the switching of many single-purpose logic gates, a chaotic chip can reconfigure all logic gates through the control of the pattern generated by the non-linear chaotic element.[8]
Impact of wetware in cognitive biology
Cognitive biology evaluates cognition as a basic biological function. W. Tecumseh Fitch, a professor of cognitive biology at the University of Vienna, is a leading theorist on ideas of cellular intentionality. The idea is that not only do whole organisms have a sense of "aboutness" of intentionality, but that single cells also carry a sense of intentionality through cells' ability to adapt and reorganize in response to certain stimuli.[9] Fitch discusses the idea of nano-intentionality, specifically in regards to neurons, in their ability to adjust rearrangements to create neural networks. He discusses the ability of cells such as neurons to respond independently to stimuli such as damage to be what he considers "intrinsic intentionality" in cells, explaining that "[w]hile at a vastly simpler level than intentionality at the human cognitive level, I propose that this basic capacity of living things [response to stimuli] provides the necessary building blocks for cognition and higher-order intentionality."[9] Fitch describes the value of his research to specific areas of computer science such as artificial intelligence and computer architecture. He states "If a researcher aims to make a conscious machine, doing it with rigid switches (whether vacuum tubes or static silicon chips) is barking up the wrong tree."[9] Fitch believes that an important aspect of the development of areas such as artificial intelligence is wetware with nano-intentionally, and autonomous ability to adapt and restructure itself.
In a review of the above-mentioned research conducted by Fitch, Daniel Dennett, a professor at Tufts University, discusses the importance of the distinction between the concept of hardware and software when evaluating the idea of wetware and organic material such as neurons. Dennett discusses the value of observing the human brain as a preexisting example of wetware. He sees the brain as having "the competence of a silicon computer to take on an unlimited variety of temporary cognitive roles."[10] Dennett disagrees with Fitch on certain areas, such as the relationship of software/hardware versus wetware, and what a machine with wetware might be capable of. Dennett highlights the importance of additional research into human cognition to better understand the intrinsic mechanism by which the human brain can operate, to better create an organic computer.[10]
Medical applications
Ethical and philosophical implications
Wetware computers may have substantial ethical implications,[13][additional citation(s) needed] for instance related to possible potentials to sentience and suffering and dual-use technology.[citation needed]
Moreover, in some cases the human brain itself may be connected as a kind of "wetware" to other information technology systems which may also have large social and ethical implications,[14] including issues related to intimate access to people's brains.[15] For example, in 2021 Chile became the first country to approve neurolaw that establishes rights to personal identity, free will and mental privacy.[16]
The concept of artificial insects[17] may raise substantial ethical questions, including questions related to the decline in insect populations.
It is an open question whether human cerebral organoids could develop a degree or form of consciousness. Whether or how it could acquire its moral status with related rights and limits[citation needed] may also be potential future questions. There is research on how consciousness could be detected.[18] As cerebral organoids may acquire human brain-like neural function subjective experience and consciousness may be feasible. Moreover, it may be possible that they acquire such upon transplantation into animals. A study notes that it may, in various cases, be morally permissible "to create self-conscious animals by engrafting human cerebral organoids, but in the case, the moral status of such animals should be carefully considered".[19]
Future applications
While there have been few major developments in the creation of an organic computer since the neuron-based calculator developed by Ditto in the 1990s, research continues to push the field forward, and in 2023 a functioning computer was constructed by researchers at the University of Illinois Urbana-Champaign using 80,000 mouse neurons as processor that can detect light and electrical signals.[20] Projects such as the modeling of chaotic pathways in silicon chips by Ditto have made discoveries in ways of organizing traditional silicon chips and structuring computer architecture to be more efficient and better structured.[8] Ideas emerging from the field of cognitive biology also help to continue to push discoveries in ways of structuring systems for artificial intelligence, to better imitate preexisting systems in humans.[9]
In a proposed fungal computer using basidiomycetes, information is represented by spikes of electrical activity, a computation is implemented in a mycelium network, and an interface is realized via fruit bodies.[21]
Prototypes
- In late 2021, scientists, including two from Pong which they learned faster than known machine intelligence systems, albeit to a lower skill-level than both AI and humans each. Moreover, the study suggests it provides "first empirical evidence" of differences in an information-processing capacity between neurons from different species as the human brain cells performed better than mouse cells.[12][25][26]
- Also in December 2021, researchers from Max Planck Institute for Polymer Research reported the development of organic low-power neuromorphic electronics which they built into a robot, enabling it to learn sensorimotorically within the real world, rather than via simulations. For the chip, polymers were used and coated with an ion-rich gel to enable the material to carry an electric charge like real neurons.[17][27]
- In 2022, researchers from the Max Planck Institute for Polymer Research, demonstrated an artificial spiking neuron based on polymers that operates in the biological wetware, enabling synergetic operation between the artificial and biological components.[28][29]
Companies active in wetware computing
Three companies are focusing specifically on wetware computing using living neurons:
- FinalSpark, Switzerland, founded in 2014
- Koniku, USA, founded in 2015
- Cortical Labs, Australia, founded in 2020
See also
- Artificial neural network
- Chemical computer
- Quantum computer
- Unconventional computing
- Wetware (brain)
- Biosensor
External links
- Biological computer born
- Neurocomputers - computers are far from comparable to human brain (Discover Magazine, September 2000)
- New material discovered for organic computers Archived 2010-02-01 at the Wayback Machine
- Wetware: A Computer in Every Living Cell
References
- ^ ISBN 9780300155440.
- ^ "Biological Computer Born". BBC News. June 2, 1999. Retrieved October 24, 2017.
- ^ a b c d e Sincell, Mark. "Future Tech". Discover. Retrieved 2023-03-29.
- ^ Popkin, Gabriel (February 15, 2015). "Moore's Law Is About To Get Weird". Nautilis. Retrieved October 25, 2017.
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- ^ a b c Ditto, William. "Construction of a Chaotic Computer Chip" (PDF). Retrieved October 24, 2017.
- ^ S2CID 54869835.
- ^ PMID 24998042.
- ^ "'Brain-on-a-chip' tests effects of biological and chemical agents, develop countermeasures". www.llnl.gov. Retrieved 26 January 2022.
- ^ a b Yirka, Bob. "A mass of human brain cells in a petri dish has been taught to play Pong". medicalxpress.com. Retrieved 16 January 2022.
- S2CID 234265462.
Biodigital technologies provide the basis for a new naturalism based on the growth of natural and synthetic organisms and systems, and a path-breaking science with very serious political, ethical and educational implications. The biologizing of information and computing is less obvious than the digitization of science and so far only in very early stages and yet it heralds a coming hybridization and interface that may be revolutionary.
- PMID 23217761. Retrieved 26 January 2022.
- ^ "Brain surgeries are opening windows for neuroscientists, but ethical questions abound". Science. Retrieved 26 January 2022.
- ^ "In the face of neurotechnology advances, Chile passes 'neuro rights' law". techxplore.com. Retrieved 26 January 2022.
- ^ a b c d Bolakhe, Saugat. "Lego Robot with an Organic 'Brain' Learns to Navigate a Maze". Scientific American. Retrieved 1 February 2022.
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- ^ Padavic-Callaghan, Karmela (2023-03-16) [16.03.2023]. "80,000 mouse brain cells used to build a living computer". New Scientist. Retrieved 2023-04-18.
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- ^ "Artificial neuron swaps dopamine with rat brain cells like a real one". New Scientist. Retrieved 16 September 2022.
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- ^ "Human brain cells in a dish learn to play Pong faster than an AI". New Scientist. Retrieved 26 January 2022.
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