Xanthogranulomatous inflammation
Xanthogranulomatous inflammation | |
---|---|
Other names | Xanthogranulomatous inflammation |
The xanthogranulomatous process (XP), is a form of acute and chronic inflammation characterized by an exuberant clustering of foamy macrophages among other inflammatory cells. Localization in the kidney and renal pelvis has been the most frequent and better known occurrence followed by that in the gallbladder but many others have been subsequently recorded.[1][2][3] The pathological findings of the process and etiopathogenetic and clinical observations have been reviewed by Cozzutto and Carbone.[4]
Location
The xanthogranulomatous type of inflammation is most-commonly seen in
A pathogenetic model might be suggested as follows:[citation needed]
- suppuration, hemorrhage and necrosis,
- granulomatous tissue with granular histiocytes and foamy macrophages,
- fibrohistiocytoma-like or plasma cell granuloma-like patterns,
- possible myofibroblast metaplasia.
A reactive fibrohistiocytic lesion simulating fibrous histiocytoma has been reported by Snover et al.[16] Reactive granular cells in sites of trauma have been regarded of histiocytic nature.[17] Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) might share several aspects of the XP. Likewise there might be some superimpositions between the XP and the plasma cell granuloma/histiocytoma-inflammatory myofibroblastic tumor complex.[18][19] The XP might be an important stage of this complex.
Histology
Destructive tumor-like masses with variable extension into adjacent fat and connective tissue can occur in cases involving organs such as kidney and gallbladder.[21]
See also
References
- S2CID 30142314.
- S2CID 22921484.
- PMID 2377572.
- ^ PMID 3054826.
- PMID 26401876. Retrieved 31 August 2015.
- .
- PMID 13712267.
- PMID 4683037.
- S2CID 38315654.
- PMID 939538.
- PMID 12984945.
- PMID 14259121.
- PMID 1251138.
- PMID 3980010.
- S2CID 6029232.
- PMID 6267932.
- PMID 4359728.
- S2CID 11510382.
- S2CID 7488307.
- ^ PMID 8822108.
- PMID 26401876. Retrieved 31 August 2015.