Yangonin
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Preferred IUPAC name
4-Methoxy-6-[(E)-2-(4-methoxyphenyl)ethen-1-yl]-2H-pyran-2-one | |
Identifiers | |
3D model (
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ChEMBL | |
ChemSpider | |
ECHA InfoCard
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100.211.821 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C15H14O4 | |
Molar mass | 258.273 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Yangonin is one of the six major
Like other kavalactones, yangonin has been found to potentiate GABAA receptors.[3] This may contribute to the anxiolytic properties of yangonin and kava as a whole.
Further in vitro studies have also demonstrated yangonin to be an inhibitor of monoamine oxidase,[citation needed] with a moderate preference for isozyme B, which could open the door to a wide range of interactions.
Toxicity
Yangonin displays marked in vitro toxicity on human hepatocytes with approximately 40% reduction in viability based on an ethidium bromide assay.[4] The predominant mode of cell death turned out to be apoptosis rather than necrosis. No significant changes were observed in glutathione levels.[4]
Biosynthesis
Yangonin is biosynthesized from coumaroyl-CoA and malonyl-CoA.
References
- ^ Malani, Joji (2002-12-03). "Evaluation of the effects of Kava on the Liver" (PDF). Fiji School of Medicine. Retrieved 2009-09-04.
- PMID 22525682.
- ^ "Yangonin".
- ^ S2CID 19717477.