2010 US Open – Wheelchair women's singles
| Wheelchair women's singles | |
|---|---|
| 2010 US Open | |
| Champion |  Esther Vergeer |
| Runner-up |  Daniela Di Toro |
| Score | 6–0, 6–0 |
Four-time defending champion Esther Vergeer defeated Daniela Di Toro in the final, 6–0, 6–0 to win the women's singles wheelchair tennis title at the 2010 US Open.
Seeds
Esther Vergeer (champion)- Sharon Walraven (semifinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| Quarterfinals | Semifinals | Finals | ||||||||||||||||||
| 1 | Esther Vergeer
| 7 | 7 | |||||||||||||||||
 Florence Alix-Gravellier
| 5 | 5 | ||||||||||||||||||
| 1 | Esther Vergeer
| 6 | 6 | |||||||||||||||||
| Jiske Griffioen
| 1 | 0 | ||||||||||||||||||
| Jiske Griffioen
| 6 | 6 | ||||||||||||||||||
| WC |  Mackenzie Soldan
| 1 | 1 | |||||||||||||||||
| 1 | Esther Vergeer
| 6 | 6 | |||||||||||||||||
| Daniela Di Toro
| 0 | 0 | ||||||||||||||||||
| Daniela Di Toro
| 6 | 7 | ||||||||||||||||||
| Aniek van Koot
| 3 | 62 | ||||||||||||||||||
| Daniela Di Toro
| 6 | 6 | ||||||||||||||||||
| 2 | Sharon Walraven
| 4 | 2 | |||||||||||||||||
 Annick Sevenans
| 4 | 3 | ||||||||||||||||||
| 2 | Sharon Walraven
| 6 | 6 | |||||||||||||||||