4-Androstenediol

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4-Androstenediol
Clinical data
Other namesAndrost-4-ene-3β,17β-diol
Routes of
administration		Oral
Identifiers
  • (3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C[C@H](CC[C@]34C)O
  • InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,13-17,20-21H,3-10H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1 checkY
  • Key:BTTWKVFKBPAFDK-LOVVWNRFSA-N checkY
 ☒NcheckY (what is this?)  (verify)

4-Androstenediol, also known as androst-4-ene-3β,17β-diol, is an

4-androstenedione, due to utilization of a different enzymatic pathway. There is also some conversion into estrogen
, since testosterone is the metabolic precursor of the estrogens.

4-Androstenediol is closer to

full agonists like testosterone or dihydrotestosterone (DHT), 4-androstenediol has antagonistic actions, behaving more like an antiandrogen.[1]

4-Androstenediol is very weakly

ERβ, respectively.[2]

Medical and commercial use

Patrick Arnold holds a 1999 patent on "Use of 4-androstenediol to increase testosterone levels in humans".[3]

References

  1. ^
    S2CID 53267316
    .
  2. PMID 9048584
    .
  3. ^ "Use of 4-androstenediol to increase testosterone levels in humans". Archived from the original on 2011-03-18. Retrieved 2011-03-18.


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