AM-2201
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AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a
full agonist for the cannabinoid receptor.[3] It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University
.
Hazards
Pharmacology
AM-2201 is a
CB2.[6] The 4-methyl functional analog MAM-2201 probably has similar affinities.[original research?] AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors.[7] AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.[7]
Pharmacokinetics
AM-2201
dealkylation produces fluoropentane instead of pentane (or plain alkanes in general).[citation needed
]
Detection
A forensic standard of AM-2201 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[8]
Legal status
In the United States, AM-2201 is a
Schedule I controlled substance.[9]
See also
References
- ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
- ^ "Substance Details AM-2201". Retrieved 2024-01-22.
- doi:10.1071/CH14198.
- S2CID 23136932.
- ^ ekaJ (20 February 2011). "The Night I Killed My Friends". Erowid.org. Retrieved 11 June 2012.
- ^ WO patent 0128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07
- ^ PMID 25921407.
- ^ "Southern Association of Forensic Scientists". Archived from the original on 2014-09-10. Retrieved 2013-07-16.
- ^ Controlled Substances listed by the DEA