AM-694

AM-694
Legal status
Legal status	AU: S9 (Prohibited substance); CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I;
Identifiers
	IUPAC name 1-[(5-Fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone;
JSmol)	Interactive image;
	SMILES Ic2ccccc2C(=O)c1cn(CCCCCF)c3ccccc13;
	InChI InChI=1S/C20H19FINO/c21-12-6-1-7-13-23-14-17(15-8-3-5-11-19(15)23)20(24)16-9-2-4-10-18(16)22/h2-5,8-11,14H,1,6-7,12-13H2 ; Key:LFFIIZFINPPEMC-UHFFFAOYSA-N ;
	(what is this?) (verify)

AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB₁. It is used in scientific research for mapping the distribution of CB₁ receptors.^[1]

Pharmacology

AM-694 is an

CB₂ with a K_i of 1.44 nM.^[2] It is unclear what is responsible for this unusually high CB₁ binding affinity, but it makes the ¹⁸F radiolabelled derivative of AM-694 useful for mapping the distribution of CB₁ receptors in the body.^[1]