Alysson Muotri

Alysson Renato Muotri is a Brazilian researcher from the

From the beginning of his academic life, Muotri was interested in studying neuroscience. Reading scientific articles led him to learn about the research carried out at the Salk Institute, especially Dr. Fred Gage's line of work, which combines stem cells with the development of new neural networks.[11]

During his post-doctoral studies at the Salk Research Institute, also in San Diego, California, Muotri was a pioneer in showing, in 2005, that human neurons derived from embryonic stem cells were capable of differentiating and functionally integrating into the brains of chimeric animals (made up of cells from two different species).^[12][13] Also in 2005, in sophisticated neurogenetic work, he revealed the activity of "jumping genes" (retrotransposable L1 elements) in neural genomes, showing that the brain is made up of a mosaic of neuronal genomes.^[14][15] The research changed the then dogma of biology, which suggested that all cells in the body shared the same genome.^[16][17]

Using cellular reprogramming (developed by Nobel laureate

In February 2014, he launched the book "Simples assim: células tronco", co-authored with the doctor Adelson Alves, published by Atheneu, with a cover illustrated by the cartoonist Ziraldo.^{[35][36][37][38]}

In April 2016, Muotri, together with other scientists, founded Tismoo [pt], the world's first personalized medicine startup focused on autism and related syndromes,^{[39][40][41][42]} with headquarters in São Paulo and two offices in the United States, in San Diego and Miami.^[43]

In May 2016, Tismoo was the first startup to publish a paper in Nature,^[44][45][46] having its research recognized in one of the world's most respected scientific journals.^[47][48][49] The paper is about the Zika virus and its relationship with the high rate of microcephaly in Brazil. Through its mini-brain technology,^[50] the Brazilian startup helped to demonstrate the relationship between the Brazilian version of the virus and how it acts to cause malformation of the cortex and leads to this neurological condition.^{[51][52][53][54]}

In December 2016, he launched the book "Espiral - Conversas Científicas do Século XXI" (Spiral - Scientific Conversations of the 21st Century), published by Atheneu, a collection of more than 200 articles published over ten years as a columnist for G1.^[55][56]

In December 2017, the Brazilian researcher discovered in an experiment with mini-brains that a drug used for 60 years against malaria, chloroquine, works as a vaccine against Zika.^{[57][58][59][60][61]}

Then, also using mini-brains, in a study published in January 2018 in the journal Scientific Reports,^[62] from the prestigious Nature group, Muotri's team says that the drug Sofosbuvir, used to treat hepatitis C, can cure Zika infection, as well as preventing the transmission of the virus from mother to baby during pregnancy.^[63]

On July 25, 2019, Muotri sent to the International Space Station (ISS), in a SpaceX capsule, an autonomous box with dozens of mini-brains, which remained in space for a month. The research aimed to verify the reaction of organoids in microgravity, for research into autism, Alzheimer's disease and other neurological conditions.^{[64][65][66][67]} And he sent the second part of this research, on December 6, 2020, to the ISS.^[68][69]

In a study published on December 8, 2020, in the scientific journal EMBO Molecular Medicine, Muotri and his team identified two candidate drugs to neutralize the deficits caused by the lack of the MECP2 gene, which causes Rett Syndrome, with laboratory tests carried out on human mini-brains at the University of California at San Diego (USA). Two drugs were used which can now begin phase three clinical trials (already approved in phases 1 and 2, proving they are safe for human consumption). The mini-brains "treated" in Muotri's laboratory began to behave as if they didn't have Rett Syndrome.^[70]

In 2023, his name was attributed for a mission to the International Space Station in November 2024 to research brain organoids.^[71][72][73] He will stay in space for about 10 days and its expedition will be financed by the University of California.^[1] Muotri will also select experiments by Brazilian scientists to carry on his flight.^[74] At the end of 2023, Muotri revealed that there is interest from Canada and South Korea in investing in the flight, but it is unclear whether the Brazilian government will have any involvement, and that biomedical researcher Livia Luz should be trained as his backup.^[75]

Controversies

Muotri has come to be considered, in some contexts, a controversial figure on the autism scene. Some autistic activists from the autistic rights movement disagree with his statements about curing autism and how he approaches the disorder in his public pronouncements.^[76] Alysson, for his part, wrote for G1 in 2013 that "there is no clear answer to autism" in relation to the dissenting positions of autistic people and,^[77] later, stated that "It is not these critics who pay my salary. Those who do, think exactly the opposite."^[78]

Works

• Simples assim: células tronco. São Paulo: Atheneu. 2014.
  ISBN 9788538804765
  .
• Espiral — Conversas Científicas do Século XXI. São Paulo: Atheneu. 2016.
  ISBN 9788538807667
  .

• 2002: Pew Latin America Postdoctoral Fellowship, La Jolla, California[79]
• 2009: NIH Director's New Innovator Award^[80]
• 2011: PopTech Science and Public Leadership Fellow^[81]
• 2013: EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration) NIMH Award^[82]
• 2014: NARSAD Independent Investigator Award^[83]

See also

• Autism spectrum
• Rett syndrome
• Tismoo [pt]
• Microcephaly
• Zika virus

References