Zika virus

Source: Wikipedia, the free encyclopedia.
This article is about the virus. For the disease, see
2015–2016 Zika virus epidemic
.
Not to be confused with
Zika virus disease
.

Zika virus
Electron micrograph of "Zika virus". Virus particles (colored purple) are 40 nm in diameter, with an outer envelope and a dense inner core.
Electron micrograph of Zika virus. Virus particles (digitally colored purple) are 40 nm in diameter, with an outer envelope and a dense inner core.[1]
"Zika virus" capsid model, colored by chains, PDB entry 5ire
Zika virus capsid model, colored by chains, PDB entry 5ire[2]
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Flasuviricetes
Order: Amarillovirales
Family: Flaviviridae
Genus: Flavivirus
Species:
Zika virus

Zika virus (ZIKV; pronounced

2015–2016 Zika virus epidemic.[7]

The infection, known as Zika fever or Zika virus disease, often causes no or only mild symptoms, similar to a very mild form of dengue fever.[5] While there is no specific treatment, paracetamol (acetaminophen) and rest may help with the symptoms.[8] As of April 2019, no vaccines have been approved for clinical use, however a number of vaccines are currently in clinical trials.[9][10][11] Zika can spread from a pregnant woman to her baby. This can result in microcephaly, severe brain malformations, and other birth defects.[12][13] Zika infections in adults may result rarely in Guillain–Barré syndrome.[14]

In January 2016, the United States Centers for Disease Control and Prevention (CDC) issued travel guidance on affected countries, including the use of enhanced precautions, and guidelines for pregnant women including considering postponing travel.[15][16] Other governments or health agencies also issued similar travel warnings,[17][18][19] while Colombia, the Dominican Republic, Puerto Rico, Ecuador, El Salvador, and Jamaica advised women to postpone getting pregnant until more is known about the risks.[18][20]

Virology

Zika virus belongs to the family

kilobase, positive-sense RNA genome. It is most closely related to the Spondweni virus and is one of the two known viruses in the Spondweni virus clade.[21][22][23][24][25]

Cross-section of Zika virus, showing the viral envelope composed of envelope proteins (red) and membrane proteins (purple) embedded in the lipid membrane (white): The capsid proteins (orange) are shown interacting with the RNA genome (yellow) at the center of the virus.[26]

A

nucleocapsid along with copies of the 12-kDa capsid protein. The nucleocapsid, in turn, is enveloped within a host-derived membrane modified with two viral glycoproteins. Viral genome replication depends on the making of double-stranded RNA from the single-stranded, positive-sense RNA (ssRNA(+)) genome followed by transcription and replication to provide viral mRNAs and new ssRNA(+) genomes.[29][30]

A longitudinal study shows that 6 hours after cells are infected with Zika virus, the vacuoles and mitochondria in the cells begin to swell. This swelling becomes so severe, it results in cell death, also known as paraptosis. This form of programmed cell death requires gene expression. IFITM3 is a trans-membrane protein in a cell that is able to protect it from viral infection by blocking virus attachment. Cells are most susceptible to Zika infection when levels of IFITM3 are low. Once the cell has been infected, the virus restructures the endoplasmic reticulum, forming the large vacuoles, resulting in cell death.[31]

There are two Zika lineages: the African lineage and the Asian lineage.

French Polynesia during the 2013–2014 outbreak.[32][33][34]

The Asian strain appears to have first evolved around 1928.[35]

Transmission

The vertebrate hosts of the virus were primarily

blood transfusions.[40] The basic reproduction number (R0, a measure of transmissibility) of Zika virus has been estimated to be between 1.4 and 6.6 .[41]

In 2015, news reports drew attention to the rapid spread of Zika in Latin America and the Caribbean.[42] At that time, the Pan American Health Organization published a list of countries and territories that experienced "local Zika virus transmission" comprising Barbados, Bolivia, Brazil, Colombia, the Dominican Republic, Ecuador, El Salvador, French Guiana, Guadeloupe, Guatemala, Guyana, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Puerto Rico, Saint Martin, Suriname, and Venezuela.[43][44][45] By August 2016, more than 50 countries had experienced active (local) transmission of Zika virus.[46]

Mosquito

Aedes aegypti predicted distribution
Global Aedes aegypti predicted distribution in 2015. The map depicts the probability of occurrence (blue=none, red=highest occurrence).

Zika is primarily spread by the female Aedes aegypti mosquito, which is active mostly in the daytime.

extrinsic incubation period in mosquitoes around 10 days.[24]

The true extent of the vectors is still unknown. Zika has been detected in many more species of Aedes, along with Anopheles coustani, Mansonia uniformis, and Culex perfuscus, although this alone does not incriminate them as vectors.[48] To detect the presence of the virus usually requires genetic material to be analysed in a lab using the technique RT-PCR. A much cheaper and faster method involves shining a light at the head and thorax of the mosquito, and detecting chemical compounds characteristic of the virus using near-infrared spectroscopy.[50]

Transmission by A. albopictus, the tiger mosquito, was reported from a 2007 urban outbreak in Gabon, where it had newly invaded the country and become the primary vector for the concomitant chikungunya and dengue virus outbreaks.[51] New outbreaks can occur if a person carrying the virus travels to another region where A. albopictus is common.[52]

The potential societal risk of Zika can be delimited by the distribution of the mosquito species that transmit it. The global distribution of the most cited carrier of Zika, A. aegypti, is expanding due to global trade and travel.[53] A. aegypti distribution is now the most extensive ever recorded – on parts of all continents except Antarctica, including North America and even the European periphery (Madeira, the Netherlands, and the northeastern Black Sea coast).[54] A mosquito population capable of carrying Zika has been found in a Capitol Hill neighborhood of Washington, DC, and genetic evidence suggests they survived at least four consecutive winters in the region. The study authors conclude that mosquitos are adapting for persistence in a northern climate.[55] Zika virus appears to be contagious via mosquitoes for around a week after infection. The virus is thought to be infectious for a longer period of time after infection (at least 2 weeks) when transmitted via semen.[56][57]

Research into its ecological niche suggests that Zika may be influenced to a greater degree by changes in precipitation and temperature than dengue, making it more likely to be confined to tropical areas. However, rising global temperatures would allow for the disease vector to expand its range further north, allowing Zika to follow.[58]

Sexual

Zika can be transmitted from men and women to their sexual partners; most known cases involve transmission from symptomatic men to women.

spermatozoa precursors.[62] Semen parameters can be altered in patients for several weeks post-symptoms onset, and spermatozoa can be infectious.[63] Since October 2016, the CDC has advised men who have traveled to an area with Zika should use condoms or not have sex for at least six months after their return as the virus is still transmissible even if symptoms never develop.[64]

Pregnancy

Zika virus can spread by vertical (or "mother-to-child") transmission, during pregnancy or at delivery.[12][65] An infection during pregnancy has been linked to changes in neuronal development of the unborn child.[66] Severe progressions of infection have been linked to the development of microcephaly in the unborn child, while mild infections potentially can lead to neurocognitive disorders later in life.[67][68][69] Congenital brain abnormalities other than microcephaly have also been reported after a Zika outbreak.[70] Studies in mice have suggested that maternal immunity to dengue virus may enhance fetal infection with Zika, worsen the microcephaly phenotype and/or enhance damage during pregnancy, but it is unknown whether this occurs in humans.[71][72]

Blood transfusion

As of April 2016, two cases of Zika transmission through blood transfusions have been reported globally, both from Brazil,[40] after which the US Food and Drug Administration (FDA) recommended screening blood donors and deferring high-risk donors for 4 weeks.[73][74] A potential risk had been suspected based on a blood-donor screening study during the French Polynesian Zika outbreak, in which 2.8% (42) of donors from November 2013 and February 2014 tested positive for Zika RNA and were all asymptomatic at the time of blood donation. Eleven of the positive donors reported symptoms of Zika fever after their donation, but only three of 34 samples grew in culture.[75]

Pathogenesis

Zika virus replicates in the mosquito's midgut epithelial cells and then its salivary gland cells. After 5–10 days, the virus can be found in the mosquito's saliva. If the mosquito's saliva is inoculated into human skin, the virus can infect epidermal keratinocytes, skin fibroblasts in the skin and the Langerhans cells. The pathogenesis of the virus is hypothesized to continue with a spread to lymph nodes and the bloodstream.[21][76] Flaviviruses replicate in the cytoplasm, but Zika antigens have been found in infected cell nuclei.[77]

The viral protein numbered NS4A can lead to small head size (microcephaly) because it disrupts brain growth by hijacking a pathway which regulates growth of new neurons.[78] In fruit flies, both NS4A and the neighboring NS4B restrict eye growth.[79]

Zika fever

Main article: Zika fever
Rash on an arm due to Zika

Zika fever (also known as Zika virus disease) is an illness caused by Zika virus.

Schwann cells.[82][85]

Diagnosis is by testing the blood, urine, or saliva for the presence of Zika virus RNA when the person is sick.[80][83] In 2019, an improved diagnostic test, based on research from Washington University in St. Louis, that detects Zika infection in serum was granted market authorization by the FDA.[86]

Prevention involves decreasing mosquito bites in areas where the disease occurs, and proper use of condoms.

2015–2016 Zika outbreak consider putting off pregnancy and that pregnant women not travel to these areas.[83][88] While no specific treatment exists, paracetamol (acetaminophen) and rest may help with the symptoms.[83] Admission to a hospital is rarely necessary.[82]

Treatment

It is advised, for an affected person with the zika virus, to drink a lot of water to stay hydrated, to lie down, and to treat the fever and agony with liquid solutions; taking drugs like acetaminophen or paracetamol helps to relieve fever and pain.[according to whom?] Referring to the US CDC it is not recommended to take anti-inflammatory and non-steroid drugs like aspirin for example.[89] If the patient affected is already taking treatment for another medical condition it is advisable to inform your attending physician before taking any other drug or additional treatment;[90]

Vaccine development

Main article: Zika virus vaccine

The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines, which are safe to use in pregnant women.[91]

As of March 2016, 18 companies and institutions were developing vaccines against Zika, but they state a vaccine is unlikely to be widely available for about 10 years.[91][92]

In June 2016, the FDA granted the first approval for a human clinical trial for a Zika vaccine.[93] In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection.[94] As of April 2017, both subunit and inactivated vaccines have entered clinical trials.[95]

History

See also: Zika fever § Epidemiology, and Zika virus outbreak timeline
Countries that have past or current evidence of Zika transmission (as of January 2016)[96]
Spread of Zika[34][97][98]
Spread of Zika in Africa and Asia, based on molecular sequence data.[22]

Virus isolation in monkeys and mosquitoes, 1947

The virus was first isolated in April 1947 from a

Ziika Forest of Uganda, near Lake Victoria, by the scientists of the Yellow Fever Research Institute.[99] A second isolation from the mosquito A. africanus followed at the same site in January 1948.[100] When the monkey developed a fever, researchers isolated from its serum a "filterable transmissible agent" which was named Zika in 1948.[101]

First evidence of human infection, 1952

Zika was first known to infect humans from the results of a serological survey in Uganda, published in 1952.[102] Of 99 human blood samples tested, 6.1% had neutralizing antibodies. As part of a 1954 outbreak investigation of jaundice suspected to be yellow fever, researchers reported isolation of the virus from a patient,[103] but the pathogen was later shown to be the closely related Spondweni virus.[104] Spondweni was also determined to be the cause of a self-inflicted infection in a researcher reported in 1956.[105]

Spread in equatorial Africa and to Asia, 1951–present

Subsequent serological studies in several African and Asian countries indicated the virus had been widespread within human populations in these regions.

IgM antibodies.[108]
In 2017, Angola reported two cases of Zika fever.[109] Zika was also occurring in Tanzania as of 2016.[110]

Micronesia, 2007

Main article: 2007 Yap Islands Zika virus outbreak

In April 2007, the first outbreak outside of Africa and Asia occurred on the island of Yap in the Federated States of Micronesia, characterized by rash, conjunctivitis, and arthralgia, which was initially thought to be dengue, chikungunya, or Ross River disease.[111] Serum samples from patients in the acute phase of illness contained RNA of Zika. There were 49 confirmed cases, 59 unconfirmed cases, no hospitalizations, and no deaths.[112]

2013–2014

Main article: 2013–2014 Zika virus outbreaks in Oceania

After October 2013 Oceania's first outbreak showed an estimated 11% population infected for French Polynesia that also presented with Guillain–Barre syndrome (GBS). The spread of ZIKV continued to New Caledonia, Easter Island, and the Cook Islands and where 1385 cases were confirmed by January 2014. During the same year, Easter Island acknowledged 51 cases. Australia began seeing cases in 2012. Research showed it was brought by travelers returning from Indonesia and other infected countries. New Zealand also experienced infections rate increases through returning foreign travelers. Oceania countries experiencing Zika today are New Caledonia, Vanuatu, Solomon Islands, Marshall Islands, American Samoa, Samoa, and Tonga.[113]

Between 2013 and 2014, further epidemics occurred in French Polynesia, Easter Island, the Cook Islands, and New Caledonia.[4]

Americas, 2015–present

Main article:
2015–2016 Zika virus epidemic
Image of a baby with microcephaly (left) compared to a normal baby (right). This is one of the potential effects of Zika virus. Signs of microcephaly may develop a few months after birth.

There was an

Public Health Emergency of International Concern.[6][115][116][117] It was estimated that 1.5 million people were infected by Zika in Brazil,[118] with over 3,500 cases of microcephaly reported between October 2015 and January 2016.[119]

A number of countries issued travel warnings, and the outbreak was expected to significantly impact the tourism industry.[6][120] Several countries have taken the unusual step of advising their citizens to delay pregnancy until more is known about the virus and its impact on fetal development.[20] With the 2016 Summer Olympics hosted in Rio de Janeiro, health officials worldwide voiced concerns over a potential crisis, both in Brazil and when international athletes and tourists returned home and possibly would spread the virus. Some researchers speculated that only one or two tourists might be infected during the three-week period, or approximately 3.2 infections per 100,000 tourists.[121] In November 2016, the World Health Organization declared that Zika virus was no longer a global emergency while noting that the virus still represents "a highly significant and a long-term problem".[122]

As of August 2017 the number of new Zika virus cases in the Americas had fallen dramatically.[123]

India, Bangladesh

On May 15, 2017, three cases of Zika virus infection in India were reported in the state of Gujarat.[124][125] By late 2018, there had been at least 159 cases in Rajasthan and 127 in Madhya Pradesh.[126]

In July 2021, the first case of Zika virus infection in the Indian state of Kerala was reported. After the first confirmed case, 19 other people who had previously presented symptoms were tested, and 13 of those had positive results, showing that Zika had been circulating in Kerala since at least May 2021.[127] By August 6th 2021, there had been 65 reported cases in Kerala.[128]

On October 22, 2021, an officer in the Indian Air Force in Kanpur tested positive for Zika virus, making it the first reported case in the Indian state of Uttar Pradesh.[129]

On 22 March 2016, Reuters reported that Zika was isolated from a 2014 blood sample of an elderly man in

retrospective study.[130]

East Asia

Between August and November 2016, 455 cases of Zika virus infection were confirmed in Singapore.[131][132]

In 2023, 722 Zika virus cases were reported in Thailand.

Robert Koch-Institut reported 29 imported Zikavirus cases imported into Germany. Of the altogether 16 imported Zika virus cases in 2023, 10 were diagnosed after a trip to Thailand with 62% of all Zika virus cases a significant relative and absolute increase.[134]

References

  1. ^ Goldsmith C (18 March 2005). "TEM image of the Zika virus". Centers for Disease Control and Prevention. Retrieved 4 March 2016.
  2. PMID 27033547
    .
  3. ^ "How to pronounce Zika". HowToPronounce.com.
  4. ^
    PMID 24983096
    .
  5. ^
    PMID 26934531
    .
  6. ^
    PMID 27013839
    .
  7. PMID 28579764
    .
  8. ^ "Symptoms, Diagnosis, & Treatment". Zika virus. Atlanta: Centers for Disease Control and Prevention. 3 March 2016. Retrieved 4 March 2016.
  9. PMID 29921914
    .
  10. PMID 28432975
    .
  11. ^ "Zika Virus Vaccines | NIH: National Institute of Allergy and Infectious Diseases". www.niaid.nih.gov.
  12. ^
    S2CID 20675635
    .
  13. ^ a b "CDC concludes Zika causes microcephaly and other birth defects". CDC. 13 April 2016. Retrieved 14 April 2016.
  14. ^ a b "Zika virus microcephaly and Guillain–Barré syndrome situation report" (PDF). World Health Organization. 7 April 2016. Retrieved 8 April 2016.
  15. ^ "Zika Virus in the Caribbean". Travelers' Health: Travel Notices. Centers for Disease Control and Prevention. 15 January 2016.
  16. PMID 26796813
    .
  17. ^ "Zika virus: Advice for those planning to travel to outbreak areas". ITV Report. ITV News. 22 January 2016. Retrieved 24 January 2016.
  18. ^ a b "Pregnant Irish women warned over Zika virus in central and South America". RTÉ News. 22 January 2016. Retrieved 23 January 2016.
  19. ^ "Zika: Olympics plans announced by Rio authorities". BBC News. British Broadcasting Corporation. 24 January 2016. Retrieved 24 January 2016. The Rio de Janeiro authorities have announced plans to prevent the spread of the Zika virus during the Olympic Games later this year. ... The US, Canada and EU health agencies have issued warnings saying pregnant women should avoid traveling to Brazil and other countries in the Americas which have registered cases of Zika.
  20. ^ a b "Zika virus triggers pregnancy delay calls". BBC News. 23 January 2016. Retrieved 23 January 2016.
  21. ^
    ISBN 978-0-7817-6060-7
    .
  22. ^
    PMID 24421913
    .
  23. PMID 24856001
    .
  24. ^
    PMID 19788800
    .
  25. PMID 17195954
    .
  26. doi:10.2210/rcsb_pdb/mom_2016_5
    .
  27. PMID 27296393
    .
  28. PMID 27158114
    .
  29. ^ "ViralZone: Zika virus (strain Mr 766)". viralzone.expasy.org. SIB Swiss Institute of Bioinformatics. Retrieved 24 August 2016.
  30. PMID 22445964
    .
  31. PMID 28473450
    .
  32. ^
    PMID 26775124
    .
  33. PMID 26061233
    .
  34. ^
    PMID 27088323
    .
  35. PMID 28315476
    .
  36. S2CID 4377569
    .
  37. PMID 22500131
    .
  38. ^ "Zika virus found in common house mosquitoes in Brazil". CNN. 22 July 2016. Retrieved 23 July 2016.
  39. ^
    PMID 27032078
    .
  40. ^
    PMID 27078190
    .
  41. ^ "Assessing the global threat from Zika virus". Science Magazine. 12 August 2016. Retrieved 15 August 2016 – via www.sciencemagazinedigital.org.
  42. ^ Moloney A (22 January 2016). "FACTBOX – Zika virus spreads rapidly through Latin America, Caribbean". Thomson Reuters Foundation News. Retrieved 26 January 2016.
  43. ^ Mitchell C (18 January 2016). "As the Zika virus spreads, PAHO advises countries to monitor and report birth anomalies and other suspected complications of the virus". Media Center. Pan American Health Organization. Retrieved 25 January 2016.
  44. ^ Mitchell C (2 February 2016). "PAHO Statement on Zika Virus Transmission and Prevention". PAHO.org. Pan American Health Organization.
  45. ^ "5 things you need to know about Zika". CNN. 24 February 2016.
  46. ^ "Zika Virus". All Countries & Territories with Active Zika Virus Transmission. Centers for Disease Control and Prevention. Archived from the original on 21 September 2017. Retrieved 15 August 2016.
  47. PMID 27721110
    .
  48. ^
    PMID 26852727
    .
  49. ^ Division of Vector-Borne Diseases, Dengue Branch. "Dengue and the Aedes aegypti mosquito" (PDF). Centers for Disease Control and Prevention. Retrieved 2 February 2012.
  50. ^ Wishart S (July–August 2018). "Shining a light on Zika". New Zealand Geographic (152): 25.
  51. PMID 24516683
    .
  52. PMID 25600600
    .
  53. PMID 26126267
    .
  54. ^ "Aedes aegypti". Health Topics: Vectors: Mosquitos. European Centre for Disease Protection and Control. Retrieved 25 January 2016.
  55. ^ Craig S, Collins B (26 January 2016). "Mosquitoes capable of carrying Zika virus found in Washington, D.C." Notre Dame News. University of Notre Dame.
  56. ^ "Zika outbreak: What you need to know". BBC News. 21 January 2016. Retrieved 31 July 2016.
  57. ^ "How to Avoid Mosquito Bites in Florida". 10 June 2013. Retrieved 31 July 2016.
  58. PMID 27564232
    .
  59. PMID 28056005
    .
  60. ^ "WHO chief going to the Olympics, says Zika risk low". Reuters. 29 July 2016. According to Margaret Chan, the director of the WHO, 'Of course, we also have learnt from the latest evidence it's not just infected men who can pass the disease to their sex partners. There was a case of a lady passing the disease to a man, so it can go both directions.'
  61. S2CID 211045539
    .
  62. PMID 30063220
    .
  63. PMID 28838639
    .
  64. PMID 27711033
    .
  65. ^ "CDC Zika: Transmission". Centers for Disease Control and Prevention. 15 April 2016. Archived from the original on 20 September 2017. Retrieved 17 April 2016.
  66. PMID 27144515
    .
  67. PMID 33544730
    .
  68. S2CID 205079825
    .
  69. S2CID 52181681
    .
  70. PMID 30424827
    .
  71. PMID 30820456
    .
  72. PMID 30737148
    .
  73. ^ "Recommendations for Donor Screening, Deferral, and Product Management to Reduce the Risk of Transfusion-Transmission of Zika Virus" (PDF). Food and Drug Administration. February 2016.
  74. ^ "Zika virus infection outbreak, Brazil and the Pacific region" (PDF). Rapid Risk Assessments. Stockholm: European Centre for Disease Prevention and Control. 25 May 2015. pp. 4–5. Archived from the original (PDF) on 13 October 2015. Retrieved 12 February 2016.
  75. PMID 24739982
    .
  76. PMID 26940504
    .
  77. PMID 2841406
    .
  78. ^ Chiu M (14 November 2019). "How maternal Zika virus infection results in newborn microcephaly". ScienMag. Retrieved 17 November 2019.
  79. PMID 32152180
    .
  80. ^ a b c d e "Zika virus". World Health Organization. January 2016. Retrieved 3 February 2016.
  81. PMID 29904223
    .
  82. ^ a b c d "Factsheet for health professionals". Health topics: Zika virus infection. European Centre for Disease Prevention and Control. 3 September 2010. Retrieved 22 December 2015.
  83. ^
    PMID 26832396
    .
  84. PMID 24909208
    .
  85. PMID 31289325
    .
  86. ^ "Zika diagnostic test granted market authorization by FDA". Washington University School of Medicine in St. Louis. 3 September 2019. Retrieved 14 February 2020.
  87. PMID 27032078
    .
  88. ^ "Brazil warns against pregnancy due to spreading virus". CNN. 24 December 2015. Retrieved 24 December 2015.
  89. ^ "Treatment for Zika Virus". CDC. 5 November 2014. Retrieved 22 December 2022.
  90. PMID 27366760
    .
  91. ^ a b "WHO and experts prioritize vaccines, diagnostics and innovative vector control tools for Zika R&D". World Health Organization. 9 March 2016. Retrieved 13 March 2016.
  92. ^ Cook J (27 January 2016). "Zika virus: US scientists say vaccine '10 years away'". BBC News. Retrieved 28 January 2016.
  93. ^ Sagonowsky E (21 June 2016). "Inovio set for first Zika vaccine human trial". fiercepharma.com. Retrieved 1 July 2016.
  94. ^ "Phase 2 Zika vaccine trial begins in U.S., Central and South America". National Institutes of Health (NIH). 31 March 2017.
  95. PMID 28432975
    .
  96. ^ "Geographic Distribution". Zika Virus. Centers for Disease Control and Prevention. 5 November 2014. Retrieved 18 January 2016.
  97. PMID 26684466
    .
  98. ^ "Zika virus in the United States". Centers for Disease Control and Prevention. Archived from the original on 20 February 2016. Retrieved 20 February 2016.
  99. ^ Cohen J (8 February 2016). "Zika's long, strange trip into the limelight". Science. American Association for the Advancement of Science. Retrieved 10 February 2016.
  100. PMID 22389730
    .
  101. ^
    PMID 27282424
    .
  102. PMID 12995441
    .
  103. PMID 13157159
    .
  104. PMID 27998553
    .
  105. PMID 13380987
    .
  106. PMID 14175744
    .
  107. ^ Austin R (10 February 2016). "Experts Study Zika's Path From First Outbreak in Pacific". The New York Times. Hong Kong. Retrieved 12 February 2016.
  108. ^ Henry M (24 May 2017). "Zika virus found to be circulating in Africa for decades". Harvard T.H.Chan School of Public Health. Retrieved 5 June 2017.
  109. ^ "Angola reports first two cases of Zika virus". Reuters. 11 January 2017. Retrieved 18 January 2017.
  110. ^ "Blood samples show presence of Zika virus in Tanzania". Anadolu Agency. Retrieved 19 December 2016.
  111. ^ Altman LK (3 July 2007). "Little-Known Virus Challenges a Far-Flung Health System". The New York Times.
  112. PMID 19516034
    .
  113. PMID 27148186
    .
  114. ^ "WHO sees Zika outbreak spreading through the Americas". Reuters. 25 January 2016. Retrieved 25 January 2016.
  115. ^ "WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain–Barré syndrome". World Health Organization. 1 February 2016. Retrieved 2 February 2016.
  116. ^ Roberts M (1 February 2016). "Zika-linked condition: WHO declares global emergency". BBC News. Retrieved 1 February 2016.
  117. ^ Pearson M (2 February 2016). "Zika virus sparks 'public health emergency'". CNN. Retrieved 2 February 2016.
  118. ^ Boadle A (18 February 2016). Brown T, Orr B (eds.). "U.S., Brazil researchers join forces to battle Zika virus". Reuters. Brasilia. Retrieved 4 March 2016.
  119. ^ "Microcephaly in Brazil potentially linked to the Zika virus epidemic, ECDC assesses the risk". News and Media. European Centre for Disease Prevention and Control. 25 November 2015. Retrieved 18 January 2016.
  120. ^ Kiernan P, Jelmayer R (3 February 2016). "Zika Fears Imperil Brazil's Tourism Push". The Wall Street Journal. Retrieved 27 February 2016.
  121. ^ Belluz J (26 May 2016). "Rio Olympics 2016: why athletes and fans aren't likely to catch Zika". Vox. Retrieved 1 June 2016.
  122. ^ "World Health Organization declares end of Zika emergency". The Irish Times. Retrieved 18 November 2016.
  123. doi:10.1126/science.aao6984
    .
  124. ^ "2017 - India". World Health Organization. 26 May 2017. Retrieved 26 October 2021.
  125. PMID 29512599.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link
    )
  126. S2CID 140302216
    .
  127. ^ "Zika Virus Disease – India". World Health Organization. 14 October 2021. Retrieved 26 October 2021.
  128. ^ "65 Zika virus cases reported in Kerala as on August 2, 2021: Health minister Mansukh Mandaviya". The Economic Times. 6 August 2021. Retrieved 26 October 2021.
  129. ^ Singh R (24 October 2021). "Zika virus case detected in Kanpur, first in Uttar Pradesh". India Today. Retrieved 26 October 2021.
  130. ^ "Bangladesh Confirms First Case of Zika Virus". Newsweek. 22 March 2016. Retrieved 22 March 2016.
  131. PMID 28527892
    .
  132. ^ "Zika Virus in Singapore". CDC. Retrieved 3 September 2016.
  133. ^ HPS Travel Health Fit for Travel (4 January 2024). "Zika virus in Thailand". www.fitfortravel.nhs.uk. Retrieved 18 January 2024.
  134. ^ Epidemiologisches Bulletin (18 January 2024). "Vermehrte Zikavirus-Fälle bei Thailandreisenden" (PDF). Robert Koch-Institut.

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External links

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