Anthony A. Hyman
Anthony Hyman | |
---|---|
Born | Anthony Arie Hyman 27 May 1962[1] |
Nationality | British |
Education | William Ellis School |
Alma mater |
|
Spouse | Suzanne Eaton |
Children | 2 |
Awards |
|
Scientific career | |
Fields | Molecular Cell Biology |
Institutions | |
Thesis | Establishment of division axes in the early embryonic divisions of Caenorhabditis Elegans (1987) |
Website | hymanlab |
Anthony Arie Hyman (born 27 May 1962) FRS MAE is a British scientist[2][3] and director at the Max Planck Institute of Molecular Cell Biology and Genetics.[4][5][6][7][8][9]
Early life and education
Hyman was born in 1962, the eldest of three children of R. Anthony Hyman, a historian of computing, and Hon. Laura Alice Boyd, daughter of the 6th Baron Kilmarnock.[10] He was educated at William Ellis School and St Marylebone Grammar School, University College London and the University of Cambridge,[1] where he was awarded a PhD in 1987.[11]
Career and research
Hyman has focused his career on examining
While at King's College, Cambridge, Hyman worked under the supervision of
At the University of California, San Francisco, Hyman investigated the interaction between chromosomes and microtubules that create the mitotic forces that separate chromosomes in the lab of Tim Mitchison. He also created a number of tools that are used today:
- atypical hydrolysable GTP analog GMPCPP[13]
- various fluorescent tubulin derivatives[14][15]
- assays for motors and microtubule polarity[16]
While at the
In 1999, Hyman became one of the four founding directors of Max Planck Institute of Molecular Cell Biology and Genetics[19] and was the Managing Director for the institute from 2010–2013. During his tenure at the MPI-CBG, Hyman and his lab members have focused on:
- Cytoplasmic organization and how cells form non-membrane bound compartments
- Size and scaling of the spindle, centrosomes, and other organelles
- Spatial control of the microtubule cytoskeleton
- Positioning of the spindle
Hyman has worked on creating parts lists for cell division among human cells as part of the EU funded projects
Hyman is currently[when?] studying the mechanisms by which cells compartmentalize their biochemistry. Of his many contributions to the field of molecular biology, he is best known for two discoveries in particular: In 2000, his team pioneered the use of RNA interference to define the "parts lists" for different cytoplasmic processes. And in 2009, while teaching a physiology course in Woods Hole, he, together with Cliff Brangwynne and Frank Julicher, made a fundamental breakthrough by being the first to observe that compartments in cells can form by phase separation. Aberrant phase transitions within liquid-like compartments may underlie amyotrophic lateral sclerosis (ALS) and other neurodegenerative and age-related diseases. Hyman's current work focuses on the physical-chemical basis by which intrinsically disordered proteins phase separate. Using this knowledge, he is studying the roles of phase separation in physiology and disease.[22]
Hyman served as a member of the Strategic Advisory Board on Science at the Wellcome Trust.[23]
Awards and honours
Anthony Hyman is honorary professor at the Faculty of Biology at
Personal life
Hyman was married to American scientist Suzanne Eaton (1959–2019); the couple had two children.[36]
References
- ^ doi:10.1093/ww/9780199540884.013.U250063. (Subscription or UK public library membershiprequired.)
- ^ Anthony A. Hyman publications indexed by Google Scholar
- ^ Anthony A. Hyman publications from Europe PubMed Central
- PMID 18166646.
- PMID 22084389.
- S2CID 4364278.
- ^ Anthony Hyman's seminars: "Organization of Cytoplasm"
- ^ Anthony Hyman's Brief Overview: "Visualizing Plus-end Growth"
- ^ Video on Anthony A. Hyman's research (Latest Thinking)
- ISBN 9781999767051.
- EThOS uk.bl.ethos.256630.
- PMID 3680373.
- PMID 1421572.
- PMID 2034137..
- PMID 1832165.
- S2CID 4335093.
- S2CID 4238425.
- S2CID 10732643.
- ^ "Max Planck Institute of Molecular Cell Biology and Genetics". Retrieved 11 December 2010.
- ^ "MitoCheck Consortium". Retrieved 24 April 2014.
- ^ "MitoSys Consortium". Retrieved 25 April 2014.
- ^ a b "Anthony Hyman – The NOMIS Foundation". nomisfoundation.ch. 13 April 2020. Retrieved 4 May 2020.
- ^ "Science Strategy Advisory Group". Wellcome. Retrieved 11 February 2023.
- ^ "DFG Leibniz Prize Winner: Prof. Dr. Anthony A. Hyman". Retrieved 25 April 2014.
- ^ "EMBO Gold Medalists – Recipients – EMBO". 20 August 2020. Retrieved 11 February 2023.
- S2CID 10703763.
- ^ "New members of Academia Europaea 2014". Academia Europaea. Retrieved 20 September 2021.
- ^ "Press Release". Leopoldina. Retrieved 20 September 2021.
- ^ "2020 NAS Election". National Academy of Sciences. Retrieved 28 April 2020.
- ^ "Biomedical Sciences | Prize". www.wiley.com. Retrieved 11 February 2023.
- ^ "Dewpoint Co-Founder Anthony Hyman Wins Prestigious Wiley Prize". Odessa American. Associated Press. Retrieved 25 February 2021.
- ^ "HFSP Nakasone Awardees". Human Frontier Science Program.
- ^ "List of members". Leopoldina. Retrieved 20 September 2021.
- ^ "Portrait Anthony Hyman". Körberstiftung. Retrieved 5 September 2022.}
- ^ "Breakthrough Prize – Winners Of The 2023 Breakthrough Prizes In Life Sciences, Mathematics And Fundamental Physics Announced". breakthroughprize.org. Retrieved 11 February 2023.
- ^ ASCB Profile: Tony Hyman. In: ASCB-Newsletter, November 2012, S. 41 (online).
Wellcome Trust,