BCCIP
| BCCIP | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 125.82 – 125.85 Mb | Chr 7: 133.31 – 133.32 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene.[5][6][7]
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]
Interactions
BCCIP has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000107949 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030983 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 11313963.
- ^ PMID 10878006.
- ^ a b "Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein".
- PMID 18773424.
External links
- Human BCCIP genome location and BCCIP gene details page in the UCSC Genome Browser.
Further reading
- Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes". Biochim. Biophys. Acta. 1125 (2): 203–9. PMID 1571364.
- Machackova E, Damborsky J, Valik D, Foretova L (2002). "Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic". Hum. Mutat. 18 (6): 545. S2CID 8549550.
- Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002). "BRCA2 gene mutations in Greek patients with familial breast cancer". Hum. Mutat. 19 (1): 81–2. S2CID 25598124.
- Robson M, Scheuer L, Nafa K, et al. (2002). "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer". J. Med. Genet. 39 (2): 126–8. PMID 11836363.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46. PMID 12527204.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Meng X, Liu J, Shen Z (2004). "Inhibition of G1 to S cell cycle progression by BCCIP beta". Cell Cycle. 3 (3): 343–8. PMID 14726710.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. PMID 15164054.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Meng X, Lu H, Shen Z (2007). "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1". Cell Cycle. 3 (11): 1457–62. PMID 15539944.
- Lu H, Guo X, Meng X, et al. (2005). "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair". Mol. Cell. Biol. 25 (5): 1949–57. PMID 15713648.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. S2CID 8235923.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Meng X, Yue J, Liu Z, Shen Z (2007). "Abrogation of the transactivation activity of p53 by BCCIP down-regulation". J. Biol. Chem. 282 (3): 1570–6. PMID 17135243.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMID 17353931.
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