Cécile Vogt-Mugnier

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Cécile Vogt-Mugnier
German Academy of Sciences Leopoldina
,
Kaiser Wilhelm Institute, now the Max Planck Institute for Brain Research
,
University of Berlin
Doctoral advisorPierre Marie

Cécile Vogt-Mugnier (27 March 1875 – 4 May 1962) was a French

cytoarchetecture studies on the brain.[1][2]

Professional life

Education and career

Vogt-Mugnier obtained her medical

Berlin, Vogt-Mugnier was awarded her medical license on January 16, 1920. Because of her scientific achievements and medical experience, she was not required to sit examinations or undergo the year of practical training.[4]

Despite her accomplishments, Vogt-Mugnier's own career and recognition remained minimal. It was only between the years 1919 and 1937 that she held a formal, paid position as a scientist at the

Kaiser Wilhelm Institute. Her position as department head corresponded to that of an extraordinary professor. For most of her life, however, she worked without compensation, and lived on her husband's earnings.[4]

Research contributions

Vogt-Mugnier and her husband's main interest was the identification and characterization of distinct regions in the neocortex by both functional and structural criteria.[6] The Vogts were attempting to precisely locate the regions in the cerebral cortex that correlate with specific brain functions. This also motivated their experimental work on electrostimulation of the cortices in 150 monkeys. In this endeavor, they collaborated with Korbinian Brodmann to map areas of the cortex and the thalamus.

The first publication produced from the couple's collaboration was a

myelination of the anterior part of the brain in the cat. The finding led to the Vogts' questioning of the German neurologist Paul Flechsig's doctrine of association centers. Together they pursued advanced neuropathological research, publishing their findings on both cyto- and myelo-architecture in the central nervous system and on the functional anatomy of the basal ganglia.[7]

In 1909, Vogt-Mugnier published La myelocytoarchitecture du thalamus du cercopithèque (

Cercopithecus), in which she reported her experiments in tracing afferent fibers to the thalamic ventral nuclear group.[8]

In 1911, Vogt-Mugnier rediscovered the so-called '

corpus striatum, characterized by slow, writhing, purposeless movements mainly affecting the hands and face.[9] This syndrome had already been described by Gabriel Anton in 1896, however his paper attracted little attention whereas Vogt-Mugnier's report brought it to the forefront of research in basal ganglia pathology.[5] Vogt-Mugnier continued to lead the pioneering work on the neuroanatomy of the thalamus and together with Hermann Oppenheim published their findings on hereditary palsy and double athetosis, in which she noted the mottled appearance of the striatum.[7]

In 1922, the Vogts defined the concept of pathoclisis through their research on insects and the human cerebral cortex.[5][10]

In January 1923, the Vogts traveled to Moscow to participate in the First All-Russian Congress for Psychoneurology. While there, they delivered a lecture on 'pathoarchitectonics and pathoclisis' and reported on their twenty-five years of experience in investigating the structures of the cerebral cortex.[11]

After 1933 the Vogts collided with the

Nazi regime over their Russian contacts and their fierce defense of their scientific independence and their collaborators, forcing Oskar to retire from their brain research institute in Berlin. However, they were able to continue their work on a smaller scale in Neustadt.[12]

Foundation of research institutes

Kaiser Wilhelm Institute for Brain Research), of which Oskar was a director.[8][14] This institute also gave rise to the Max Planck Institute for Brain Research in 1945.[4]

In 1936, Vogt-Mugnier accompanied her husband to Southern Germany where they established the Institut für Hirnforschung und allgemeine Biologie (Institute of Brain Research and General Biology) in Neustadt.[1]

In 1959, the Vogts founded the Cécile and Oskar Vogt Institute for Brain Research. This was taken over in 1964 by the

University of Düsseldorf and remains one of the largest collections of brain slices in the world.[15]

Despite never achieving a formal position of power in these institutes, Vogt-Mugnier was described by former collaborator Adolf Hopf as having significant control over the organizational work:

[She took on] not merely the difficult tasks of administration and financing but also the internal organisation of the institute down to the last detail. She made sure that the methods of brain study met and maintained the highest standards. The collection of animal and human brain sections, the largest in the world... was in a sense her personal property; she was familiar with each case and each section; without her help, many staff members would not have been able to use the collection.[4]

Honors and accomplishments

In 1924, Vogt-Mugnier became co-editor of the Journal für Psychologie und Neurologie (Journal for Psychology and Neurology) along with her husband. The journal appeared under their joint direction after 1954 as the Journal für Hirnforschung (Journal for Brain Research), published by the Akademie Verlag in East Berlin.[4]

National Prize of East Germany, and she became a member of the German Academy of Sciences at Berlin.[16] Vogt-Mugnier also received honorary doctorates from the Universities of Freiburg and Jena[9] and the Humboldt University of Berlin.[4]

The Vogt couple later received public attention through the novel Lenin's Brain by

Lenin after his death. In 1998, Helga Satzinger published the book Die Geschichte der genetisch orientierten Hirnforschung von Cécile und Oskar Vogt in der Zeit von 1895 bis ca. 1927 (The history of genetically oriented brain research by Cécile and Oskar Vogt from 1895 to circa 1927) documenting their work.[17]

Personal life

Early life

Cécile Vogt-Mugnier was born Augustine Marie Cécile Mugnier in

Annecy, France and she lost her father when she was only two years old. A wealthy and devoutly religious aunt paid for her education at a convent school, but Cécile rebelled against the system shortly after her first communion. Disinherited, she returned to live with her mother but continued with her studies. She prepared for her baccalauréat examinations with private teachers and obtained a bachelor's degree in science. At the age of eighteen she became one of the very few women to be admitted to the medical school in Paris.[4][12]

Family

In 1897, 22-year-old Cécile Vogt-Mugnier found herself pregnant, unmarried, and in the middle of earning a medical degree.

Augusta Marie Dejerine-Klumke, who collaborated with him). Little is known about their first meetings in 1898, except that they hardly understood each other's language.[12] They married against Oskar's mother's wishes in 1899.[17] The Vogt couple collaborated on their research for sixty years, usually with Cécile as the primary author. The Vogts had three daughters, all accomplished scientists in their own rights.[19]

Personality

As a young child, Vogt-Mugnier was described as already having "an independent and unconventional mind". The neurologist

Schwarzwald (from 1946 to 1949), described her as a liberal woman with humanistic ideals:

I must admit that Cécile influenced me and my development. It was not just a question of scientific things but more about understanding and enjoying life. She taught, for example, the philosophy of a French meal, how the wines should be selected for the different phases. She had a very generous, philosophic view of the problems of life, both in family and everyday work. She was a teacher in the art of living, of which she could give any a good advice... She was probably the most intelligent person I ever met.[7]

According to Klatzo many thought that Vogt-Mugnier was the most distinguished of the Vogt couple and that it was she who had developed the basic ideas for their work on the basal ganglia. Despite this, she remained in the background, taking on the role of caring wife and mother, supporting Oskar and defending his actions.

The neurosurgeon Wilder Penfield met the couple in 1928 and recalled Vogt-Mugnier:

Oskar Vogt's wife listens while she looks at something remote with her widely separated eyes and laughs. She is tall and she laughs almost continuously. She seems unaware that her glasses are about to fall off her nose, that the maid makes noises with things at the table so her husband has to correct her. Her attention is eagerly on one thing – her husband's unstoppable flow of learned conversation.[7]

Her intelligence often surprised people and left those who encountered her with a lasting impression:

It was not easy to get close, on a human level, to Dr Cécile Vogt's highly intellectual nature. Her profound understanding of human beings was paired with a probing analysis, which many a visitor or staff member found it difficult to withstand. This cool matter-of-fact manner concealed a warm heart, however.[4]

Late life

Later in their career, the Vogts turned their focus to genetics, experimenting with insects that they had collected on their holiday trips to the Caucasus, the Balkans, North Africa, and the Balearic Islands. Their younger daughter Marguerite pursued this research for some ten years before departing to California.[7]

They continued their work until Oskar died in 1959, and after the death of her husband Vogt-Mugnier moved to

Cambridge, England to be with their elder daughter Marthe. Cécile died there in 1962.[7]

References

  1. ^ a b "Biographies". Max Delbrück Center. Max-Delbrück-Centrum für Molekulare Medizin. Archived from the original on 13 March 2016. Retrieved 6 May 2014.
  2. ISBN 978-3-211-00919-2
    . Retrieved December 24, 2012.
  3. S2CID 42773566
    .
  4. ^ a b c d e f g h i Helga Satzinger – Femininity and Science: The Brain Researcher Cécile Vogt (1875-1962) Archived 2016-03-04 at the Wayback Machine. Translation of: Weiblichkeit und Wissenschaft. In: Bleker, Johanna (ed.): Der Eintritt der Frauen in die Gelehrtenrepublik. Husum, 1998, 75-93.
  5. ^
    ISBN 978-3-8440-0367-3
    .
  6. ^
    ISBN 978-0-08-052890-8
    .
  7. ^ a b c d e f "Cécile Vogt". Whonamedit?. 2014. Retrieved 6 May 2014.
  8. ^
    S2CID 26720830
    .
  9. ^ a b "Vogt-Vogt syndrome (Cécile and Oskar Vogt)". Whonamedit?. 2014. Retrieved 6 May 2014.
  10. ^ Vogt, Cécile; Vogt, Oskar (1922). "Erkrankungen der Großhirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik". J Psychol Neurol. 28: 8–171.
  11. ISBN 978-0-8020-9171-0
    .
  12. ^
    S2CID 12623242
    .
  13. ISBN 978-0-521-87906-4
    .
  14. ^ "Origins". MPI Brain Research. Max Planck Institute for Brain Research. 2012. Retrieved 6 May 2014.
  15. ^ "Cécile und Oskar Vogt-Institut für Hirnforschung GmbH". Unifreunde-Duesseldorf. Gesellschaft von Freunden und Förderernder Heinrich-Heine-Universität Düsseldorf e.V. Archived from the original on 7 May 2014. Retrieved 6 May 2014.
  16. ^ Komander, Gerhild (December 2004). "Vogt, Cécile". Die Geschichte Berlins. Retrieved 9 May 2014.
  17. ^
    S2CID 73163927
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  18. ^ Campbell, Olivia (2021-05-20). "A Mother of 3 Maps the Brain". Beyond Curie. Retrieved 2024-04-04.
  19. ISBN 978-0-415-92040-7
    . Cécile Vogt-Mugnier.
  20. ^ "Claire Vogt: A forgotten talented daughter - WiNEu". 2020-04-29. Retrieved 2024-04-04.
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