Campylobacter coli

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Campylobacter coli
Scientific classification
Domain:	Bacteria
Phylum:	Campylobacterota
Class:	"Campylobacteria"
Order:	Campylobacterales
Family:	Campylobacteraceae
Genus:	Campylobacter
Species:	C. coli
Binomial name
Campylobacter coli (Doyle, 1948) Véron and Chatelain, 1973

Campylobacter coli is a

In the year 1886, Theodor Escherich established that spiral form bacteria were noted in the stool specimen and large intestinal mucous of neonates (an infant less than 4 weeks), and kittens. However, it was not until 1957, as widely spread as the bacteria were, Campylobacter was still not implicated in the human diarrhea. Further to this, in 1973, Campylobacter was proposed as a novel genus.^[4]

Pathogenicity and transmission

Campylobacter coli are thought to be mainly transmitted to humans via handling and eating raw or undercooked meat or other contaminated food products, but due to their broad natural reservoir, they can also be transmitted via soil and water.^[5] Other known sources of Campylobacter infections include food products, such as unpasteurised milk and contaminated fresh produce.^[6] The infectious dose of Campylobacter ranges between 1000 and 10,000, but even 500–800 colony forming units (CFU) has also been reported to cause disease. The bacteria can also be transmitted to humans via direct contact with infected animals. Usually the incubation time after ingestion ranges between 24 and 72 hours, but incubation times up to a week have been reported.^[7] The adhesion to eukaryotic cells is mediated by several proteins, including the Campylobacter adhesion to fibronectin protein (CadF), which binds specifically to fibronectin in the cell membrane.^[8]

Virulence factors

Campylobacteriosis seems to be dependent on several virulence factors involving adhesion, invasion and bacterial motility adherence. Campylobacter secrete a cytolethal distending toxin (CDT), which is an AB toxin composed of three subunits encoded by cdtA, cdtB and cdtC. This toxin has DNase activity, which causes DNA double-strand breaks during the cell cycle G2 phase, leading eventually to cell apoptosis in HeLa and Caco-2 cells.^[9]

Survival

Campylobacter are microaerophilic, fastidious organisms that become stressed in aerobic condition, temperature variations, osmotic balances, and starvation ^{[citation needed]}. However, in the community of Campylobacter species, C. coli has been discovered to be more aerotolerant than C. jejuni; this explains the increasing survival and transmission of the strains during stressful processing and storage conditions (Karki et al., 2019).^{[citation needed]}

Human infection

Campylobacteriosis is characterized by symptoms including high fever, headache, nausea, abdominal cramps, and diarrhoea, sometimes bloody. Foodborne infections caused by Campylobacter spp. can be diagnosed by isolation of the organism from faeces and identification by growth-dependent tests, immunological assays, or genomic analyses.^[10]

Treatment

Campylobacteriosis is often self-limiting infection, which is treated according to the symptoms, for example with electrolyte replacement and rehydration. While extra fluid is required of an infected person for as long as the symptoms lasts,