Cornea plana 1
| Cornea plana 1 | |
|---|---|
| Other names | Autosomal Dominant Cornea Plana, CNA1. |
autosomal dominant manner. | |
| Specialty | Ophthalmology |
Cornea plana 1 (CNA1) is a
autosomal dominant disorder.[3]
Signs and symptoms
Cornea plana commonly presents as a flat
arcus lipoides, low anterior chamber depth, and an indistinct border between the sclera and cornea due to a decreased angle between the two.[2] Although a small corneal diameter is anticipated, measuring it can be challenging because the scleral tissue overlaps the cornea by a few millimeters. In the patients who have been described, the anterior chamber depth has been found to vary from 0.8 to 2.1 mm.[3]
Moreover, high
hyperopia, myopia has been identified in a few cases.[5] As many as 90 percent of cases have a bilateral presentation, which is linked to sclerocornea.[1] Finally, congenital ptosis has also been reported, and the absence of corneal protrusion is most likely the cause.[3]
Diagnosis
Clinical presentation, keratometry,[5] pachymetry, and endothelial imaging are used to make the diagnosis.[6]
Since the decreased refraction in the autosomal recessive form is more severe than in the autosomal dominant form, corneal refraction measurements can be used to differentiate between CNA1 and CNA2.[3]
Histology is distinguished by
Bowman's membrane defects, and stromal vascularization and scar formation.[7]
See also
References
Further reading
- Khan, Arif O. (2012). "Cornea Plana". Genetic Diseases of the Eye. Oxford University Press. pp. 85–91. ISBN 978-0-19-532614-7.
- Coleman, Michael (2018). "Cornea Plana". Encyclopedia of Ophthalmology. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 513–514. ISBN 978-3-540-68292-9.