Cyclin T2
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 2: 134.92 – 134.96 Mb | Chr 1: 127.7 – 127.74 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene.[5][6][7]
Function
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.[7]
Interactions
Cyclin T2 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000082258 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026349 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9499409.
- PMID 10465067.
- ^ a b "Entrez Gene: CCNT2 cyclin T2".
- S2CID 44657967.
Further reading
- Wolff A (1976). "[Problem of occupational disability hazards]". Lebensversicher Med. 28 (3): 76–7. PMID 9544.
- Wimmer J, Fujinaga K, Taube R, Cujec TP, Zhu Y, Peng J, Price DH, Peterlin BM (1999). "Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b". Virology. 255 (1): 182–9. PMID 10049833.
- Kwak YT, Ivanov D, Guo J, Nee E, PMID 10329126.
- PMID 10364329.
- Herrmann CH, Mancini MA (2001). "The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions". J. Cell Sci. 114 (Pt 8): 1491–503. PMID 11282025.
- Nguyen VT, Kiss T, Michels AA, Bensaude O (2001). "7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes". Nature. 414 (6861): 322–5. S2CID 4341651.
- Tolstonog GV, Mothes E, Shoeman RL, Traub P (2001). "Isolation of SDS-stable complexes of the intermediate filament protein vimentin with repetitive, mobile, nuclear matrix attachment region, and mitochondrial DNA sequence elements from cultured mouse and human fibroblasts". DNA Cell Biol. 20 (9): 531–54. PMID 11747605.
- Simone C, Bagella L, Bellan C, Giordano A (2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene. 21 (26): 4158–65. S2CID 44657967.
- Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. PMID 12832472.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMID 15302935.
- Kurosu T, Zhang F, Peterlin BM (2004). "Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb". Gene. 343 (1): 173–9. PMID 15563843.
- Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription". Mol. Cell. 19 (4): 523–34. PMID 16109376.
- Cottone G, Baldi A, Palescandolo E, Manente L, Penta R, Paggi MG, De Luca A (2006). "Pkn is a novel partner of cyclin T2a in muscle differentiation". J. Cell. Physiol. 207 (1): 232–7. S2CID 7382847.
- Simone C, Giordano A (2007). "Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells". Cell Death Differ. 14 (1): 192–5. PMID 16841087.
- Fu J, Yoon HG, Qin J, Wong J (2007). "Regulation of P-TEFb elongation complex activity by CDK9 acetylation". Mol. Cell. Biol. 27 (13): 4641–51. PMID 17452463.
External links
PDB gallery | |
|---|---|
|
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |