Cytokeratin 5/6 antibodies

Cytokeratin 5/6 antibodies are

cytokeratin 6.^[1] These are used in immunohistochemistry, often called CK 5/6 staining,^[2]

Identifying basal cells or myoepithelial cells in the breast and prostate.^[1]
For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative.^[1] Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary carcinoma (Cyclin D1 > 37.00%, CK 5/6 negative).^[2]
In the lung, distinguishing epithelioid
lung adenocarcinoma (CK5/6 negative in 85%).^[1]

References

^ ^a ^b ^c ^d Robert Terlević, Semir Vranić. "Cytokeratin 5/6". Topic Completed: 3 June 2019. Revised: 8 December 2019
^
PMC 3571902
.

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