David W. Wood

Add links
Source: Wikipedia, the free encyclopedia.
David W. Wood
EducationRensselaer Polytechnic Institute (M.S. & Ph.D.), California Institute of Technology (Caltech, B.S.)
Scientific career
InstitutionsOhio State University, Princeton University, Amgen, Bristol Myers Squibb, CP Kelco
ThesisGeneration and application of a self-cleaving protein linker for use in single-step affinity fusion based protein purification (2000)
Doctoral advisorsGeorges Belfort, Marlene Belfort
Websitehttps://cbe.osu.edu/wood-laboratory-applied-protein-engineering

David W. Wood (born in 1967) is an American chemical engineer who is Professor of Chemical and Biomolecular Engineering at Ohio State University. Wood is also associated with the Department of Chemistry and Biochemistry and Molecular Biophysics Training Program.

Wood is best known for his work on self-removing affinity tag methods, which he first published in Nature Biotechnology[1] while a Ph.D. student at Rensselaer Polytechnic Institute. This method was also patented as a part of a collaboration with co-inventors at the Wadsworth Center of the New York State Department of Health and Rensselaer Polytechnic Institute, including Marlene Belfort, Georges Belfort, Victoria Derbyshire, and Wei Wu.[2]

Early life and education

Wood received dual undergraduate degrees in biology and chemical engineering from the

Frances H. Arnold. He earned his Ph.D. in chemical engineering from Rensselaer Polytechnic Institute in 2000. His doctoral co-advisors were Georges Belfort at Rensselaer Polytechnic Institute, and Marlene Belfort at Wadsworth Center.[3]

Career

After obtaining his undergraduate degrees, Wood started working on high-viscosity

immunocompromised cancer patients after undergoing chemotherapy or radiation treatment.[4] Wood worked on the GMP fermentation team to manufacture Neupogen (rhG-CSF) between 1991-1993. Neupogen became one of the most successful biotech drugs at that time and second blockbuster for Amgen after Epogen.[citation needed
]

In 1993, Wood joined the group of Georges Belfort

intein.[1][6][7][8] After earning his Ph.D. he joined a team at Bristol Myers Squibb in Hopewell, New Jersey
. This time he focused on the recovery and in vitro processing of transgenic monoclonal antibody therapeutics.

In 2001, Wood started his academic career at Princeton University as an Assistant Professor of Chemical and Biological Engineering, where he continued his research focusing on self-removing tags, protein engineering, and applied biosensors.[9][10][11][12][13] In 2009, he joined the Chemical and Biomolecular Engineering Department at Ohio State University as an Associate Professor and soon after was appointed as a Full Professor.[citation needed][3] While at the Ohio State, he continued to explore additional applications, including the development of multitarget sRNAs that can be used for metabolic engineering, and the modification of human butyrylcholinesterase for the degradation of the chemical warfare nerve agents in collaboration with the Battelle Memorial Institute.[14][15]

Wood has joint appointments with Department of Chemistry and Biochemistry and the Molecular Biophysics Training Program at the Ohio State University. He is one of a small group of researchers worldwide focusing on intein implementation in various applications, along with Belfort and Tom Muir.[16][17]

Wood's research focuses on developing new technologies by recombining protein domains, particularly in biopharmaceutical development and manufacturing. He has continued refining these methods for biopharmaceutical development and manufacturing, and his work has drawn funding from the

US Army Research Office, projects as well as several industry sponsors.[18][19][20][21][22][23] Wood was also involved in the development of protein switches for biotechnology funded by the NSF Career Award.[24] Wood is an author of over 60 publications, six issued patents, two additional patent applications pending and an additional dozen book chapters or edited volumes. His publications have been cited nearly 4000 times.[25]

Wood is a member of the American Chemical Society, BIOT division, American Institute of Chemical Engineers, and International Society of Pharmaceutical Engineers.[citation needed][3]

Awards and honors

  • 2003: NSF Career Award[24]
  • 2016: Lumley Engineering Research Award, Ohio State College of Engineering[26]

Business

Protein Capture Science[27] is a biotech start-up company commercializing a self-removing affinity tag technology for research and large-scale purifications of proteins.[28][29] Wood and Izabela Gierach are co-founders of the company, based in Columbus, Ohio. The first line of the iCapTag products for protein purification was showcased in the Industry Innovators 2021-2022 Issue of the journal BioProcess International.[30] Protein Capture Science was recently awarded several grants and funding, including highly competitive The Ohio Third Frontier Technology Validation and Start-Up Fund and the Concept Fund for extraordinary technologies by the Department of Development, State of Ohio.[31]

References

  1. ^
    S2CID 13247413
    .
  2. ^ US 6933362, Belfort, Marlene; Belfort, Georges & Derbyshire, Vicky et al., "Genetic system and self-cleaving inteins derived therefrom, bioseparations and protein purification employing same, and methods for determining critical, generalizable amino acid residues for varying intein activity", published 2005-08-23, assigned to Rensselaer Polytechnic Institute 
  3. ^ a b c "William G. Lowrie Department of Chemical and Biomolecular Engineering, David Wood biography, the Ohio State University". 17 July 2020.
  4. ^ "Amgen History". Amgen, Inc. Retrieved 2022-07-27.
  5. ^ "Georges Belfort | The Howard P. Isermann Department of Chemical and Biological Engineering". cbe.rpi.edu. Retrieved 2022-07-27.
  6. PMID 9326633
    .
  7. S2CID 12491649
    .
  8. OCLC 1150068137.[page needed
    ]
  9. S2CID 24647545
    .
  10. PMID 15632292
    .
  11. PMID 17569534
    .
  12. S2CID 3190373
    .
  13. PMID 21893405
    .
  14. PMID 28067500
    .
  15. PMID 31879758
    .
  16. PMID 35463948
    .
  17. ISBN 3-540-25106-5
    .
  18. ^ "NSF Award Search: Award # 1264322 - Highly Controllable Self-cleaving Tags for Biopharmaceutical Research and Manufacturing Purification Platforms". www.nsf.gov. Retrieved 2022-07-27.
  19. ^ "Just-in-time therapeutics manufacturing project receives additional DARPA funding". COLLEGE OF ENGINEERING. 2015-07-28. Retrieved 2022-07-27.
  20. ^ "Graduate students in the Frey Laboratory at UMBC". userpages.umbc.edu. Retrieved 2022-07-27.
  21. ^ "Ohio State engineering faculty attract $3.3 million in NSF funding in June". COLLEGE OF ENGINEERING. 2013-07-03. Retrieved 2022-07-27.
  22. ^ "Advancing the science and engineering of artificial blood". Chemical and Biomolecular Engineering. 2021-02-22. Retrieved 2022-07-27.
  23. S2CID 15569524
    .
  24. ^ a b "NSF Award Search: Award # 0348220 - CAREER: Protein Switches for Molecular Biotechnology". www.nsf.gov. Retrieved 2022-07-27.
  25. ^ "David W. Wood". scholar.google.com. Retrieved 2022-07-27.
  26. ^ "David Wood's research recognized with Lumley Award". Chemical and Biomolecular Engineering. 2016-04-18. Retrieved 2022-07-27.
  27. ^ "Protein Capture Science". www.proteincapturescience.com. Retrieved 2022-07-27.
  28. ^ "Protein Capture Science Seeks to Accelerate Biomedical Research". Rev1 Ventures. 2021-05-20. Retrieved 2022-07-27.
  29. ^ "Protein Capture Science Accelerates Medical Therapies". Rev1 Ventures. 2022-04-15. Retrieved 2022-07-27.
  30. ^ "iCapTag Tagless Protein Purification Platform". BioProcess International. 2021-08-25. Retrieved 2022-07-27.
  31. ^ Ohio Advancing Cutting-Edge Technology, Third Frontier Accelerating New Ideas and Solutions.https://development.ohio.gov/static/business/thirdfrontier/2020%2006%2024%20Ohio%20Advancing%20Cutting-Edge%20Technology.pdf. Retrieved 2022-07-27

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=David_W._Wood&oldid=1182996898"