Draft:Balon (protein)

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Balon
A rendering of Msmeg1130 (Balon analogue) in a complex with the Mycobacterium smegmatis ribosome. Balon in tan in the center.
Identifiers
Symbol?
Msmeg1130 rotating structure

Balon is a hibernation factor protein found in the cold-adapted bacterium

A site of the ribosome, as other hibernation factors do, binding near to but not across the channel, allowing it to attach to the ribosome independent of whether protein production is taking place.[2] Balon was discovered accidentally by a researcher who unintentionally left a sample of P. urativorans in an ice bucket for too long, cold-shocking it, through subsequent cryo-EM scans of the organism's ribosomes.[2]

Relatives of Balon have been found to also bind to the ribosome's A-site in Mycobacterium tuberculosis, which causes tuberculosis, and Thermus thermophilus, which lives in thermal vents, suggesting that it has similarly acting homologues in other species.[2] Genetic relatives of Balon have been found in 20% of bacterial genomes catalogued in public databases, but are absent from Escherichia coli and Staphylococcus aureus, the most widely used models for cellular dormancy.[2]

References

  1. ^
    PMID 38355796
    .
  2. ^ a b c d e f Samorodnitsky, Dan (2024-06-05). "Most Life on Earth is Dormant, After Pulling an 'Emergency Brake'". Quanta Magazine. Retrieved 2024-06-09.
  3. ^ York, University of. "York research delivers new understanding of cells' survival ability". University of York. Retrieved 2024-06-09.