Dutch hypothesis
The Dutch hypothesis provides one of several
aetiologically linked to environmental insults such as tobacco smoke.[1]
The Dutch hypothesis was originally proposed by Dick Orie and his team in 1961 at the
determinants of the life-threatening disease, COPD (in the Netherlands, the term chronic non-specific lung disease was adopted as an umbrella term for asthma and COPD).[citation needed
]
More recent
polymorphisms in people with asthma and COPD provide support for the notion that the two conditions share some biological characteristics; implicated genes include ADAM33, CCL5 and IL17F.[5]
Although clinically debated,alpha 1-antitrypsin overexpression and consequent alpha-1 proteinase deficiency), the British hypothesis (regarding a putative aetiological role of acute bronchial infections), and the autoimmunity hypothesis.[1]
References
- ^ PMID 22793938.
- ^ .
- ISBN 978-0-19-512582-5. Retrieved 19 November 2012.
- ISBN 978-1-119-96373-8. Retrieved 15 November 2012.
- PMID 19628974.
- PMID 16864716.
- PMID 16864717.