Enzyme induction and inhibition

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Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme.

Enzyme inhibition can refer to

• the inhibition of the expression of the enzyme by another molecule
• interference at the enzyme-level, basically with how the enzyme works. This can be competitive inhibition, uncompetitive inhibition, non-competitive inhibition or partially competitive inhibition.

If the molecule induces enzymes that are responsible for its own metabolism, this is called auto-induction (or auto-inhibition if there is inhibition). These processes are particular forms of gene expression regulation.

These terms are of particular interest to pharmacology, and more specifically to drug metabolism and drug interactions. They also apply to molecular biology.

History

In the late 1950s and early 1960s, the French molecular biologists

• Aryl hydrocarbon receptor

Potency

Index inducer or just inducer predictably induce metabolism via a given pathway and are commonly used in prospective clinical drug-drug interaction studies.^[2]

Strong, moderate, and weak inducers are drugs that decreases the AUC of

External links

• Enzymologic+Gene+Expression+Regulation at the U.S. National Library of Medicine Medical Subject Headings (MeSH)